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Hepatitis B virus X protein promotes the growth of hepatocellular carcinoma by modulation of the Notch signaling pathway

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Gastroenterol & Hepatol, Wuhan 430030, Peoples R China

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关键词： HBx HepG2 Notch NICD DAPT

摘要：

Hepatitis B virus X protein (HBx) plays a crucial role in the development of hepatocellular carcinoma (HCC), however, little is known about the mechanism. Here, we investigated the relationship between HBx and Notch signaling in HepG2 cells after they were transfected with the HBx gene. It was found that HBx upregulated the expression of Notch-1, Jagged-1 and Hes-1 at the transcriptional level by binding to the Notch-1 intracellular domain, which is congruent with the observations of enhanced malignant biological activities of HBx-transfected HepG2 cells compared with normal HepG2 cells. However, while Notch signaling was blocked, the HBx-induced abnormalities were partially reversed. These findings suggest that HBx may promote the progression of HCC via the activated Notch pathway.

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出版当年[2011]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

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出版当年[2010]版：

Q3 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 3.8 最新[2023版] 3.4 最新五年平均 1.686 出版当年[2010版] 1.679 出版当年五年平均 1.588 出版前一年[2009版] 1.835 出版后一年[2011版]

第一作者：

第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Gastroenterol & Hepatol, Wuhan 430030, Peoples R China

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通讯机构： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Gastroenterol & Hepatol, Wuhan 430030, Peoples R China [*1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Gastroenterol & Hepatol, 1095 Jiefang St, Wuhan 430030, Peoples R China

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相关文献

[1]Activated Notch signaling is required for hepatitis B virus X protein to promote proliferation and survival of human hepatic cells [2]Effects of Notch1 signaling in L02 cell malignant transformation induced by HBV X protein [3]Crosstalk between Notch1 and Wnt/β-catenin pathways in the development of HBx associated HCC [4]HBx基因下调miR-192对人肝癌细胞株HepG2周期的影响 [5]FAM129A promotes self-renewal and maintains invasive status via stabilizing the Notch intracellular domain in glioma stem cells [6]Effects of the Notch signalling pathway on hyperoxia-induced immature brain damage in newborn mice [7][HBx gene down-regulates miR-192 expression and inhibits apoptosis of human hepatoma cell line HepG2]. [8]Notch signaling activation contributes to paclitaxel-induced neuropathic pain via activation of A1 astrocytes [9]Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells [10]乙型肝炎病毒X基因下调miR-192对人肝癌细胞株HepG2凋亡的影响