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FAM129A promotes self-renewal and maintains invasive status via stabilizing the Notch intracellular domain in glioma stem cells

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资源类型：
Pubmed体系：
作者：
Liu Guohao[1] * ; Zhang Po[2] * ; Chen Sui[1] ; Chen Zirong[1] ; Qiu Yanmei[3] ; Peng Peng[4] ; Huang Wenda[1] ; Cheng Fangling[5] ; Zhang Yang[6] ; Li Huan[6] ; Xiao Qungen[1] ; Mao Feng[1] ; Wang Baofeng[1] ; Jiang Xiaobing[2] ; Wan Feng[7] ; Guo Dongsheng[1,*2] ; Yu Xingjiang[6,*1] ;
单位： [1]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [3]Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [4]Department of Neurosurgery, Xiangyang Central Hospital, Affiliated Hospital to Hubei University of Arts and Science, Xiangyang, China. [5]Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [6]Department of Histology and Embryology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [7]Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
出处：
DOI： 10.1093/neuonc/noad079
ISSN：

关键词： glioma stem cell tumor invasion Notch pathway NICD FAM129A

摘要：
Glioma stem cells (GSCs) are a subpopulation of tumor cells with self-renewal and tumorigenic capabilities in glioblastomas (GBMs). Diffuse infiltration of GSCs facilitates tumor progression and frustrates efforts at effective treatment. Further compounding this situation is the currently limited understanding of what drives GSC invasion. Here we comprehensively evaluated the significance of a novel invasion-related protein, Family with Sequence Similarity 129 Member A (FAM129A), in infiltrative GSCs.Western blotting, immunohistochemistry, and gene expression analysis were used to quantify FAM129A in glioma specimens and cancer datasets. Overexpression and knockdown of FAM129A in glioma stem cells were used to investigate its effects on tumor growth and invasion. RNA-seq, qRT-PCR, western blotting, and co-precipitation assays were used to investigate FAM129A signaling mechanisms.FAM129A is preferentially expressed in invasive frontiers. Targeting FAM129A impairs GSC invasion and self-renewal. Mechanistically, FAM129A acted as a positive regulator of Notch signaling by binding with the Notch1 intracellular domain (NICD1) and preventing its degradation.FAM129A and NICD1 provide a precise indicator for identifying tumor margins and aiding prognosis. Targeting them may provide a significantly therapeutic strategy for GSCs.© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.

基金：
i) HUST Academic Frontier Youth Team, ii) Huazhong University of Science and Technology Independent Innovation Research Fund Project (NO.2019kfyXJJS187), and iii) National Natural Science Foundation of China (NO. 81874086, NO.81974452 and NO. 82072797).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学 1 区 肿瘤学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学 1 区 肿瘤学
第一作者：
第一作者单位： [1]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [6]Department of Histology and Embryology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [*1]Department of Histology and Embryology, College of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China [*2]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China.
推荐引用方式(GB/T 7714)：
Liu Guohao,Zhang Po,Chen Sui,et al.FAM129A promotes self-renewal and maintains invasive status via stabilizing the Notch intracellular domain in glioma stem cells[J].Neuro-oncology.2023,doi:10.1093/neuonc/noad079.
APA：
Liu Guohao,Zhang Po,Chen Sui,Chen Zirong,Qiu Yanmei...&Yu Xingjiang.(2023).FAM129A promotes self-renewal and maintains invasive status via stabilizing the Notch intracellular domain in glioma stem cells.Neuro-oncology,,
MLA：
Liu Guohao,et al."FAM129A promotes self-renewal and maintains invasive status via stabilizing the Notch intracellular domain in glioma stem cells".Neuro-oncology .(2023)

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