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Predictors of vascular events after ischemic stroke: The China Ischemic Stroke Registry Study

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单位: [a]Institute of Neurology, Fudan University, Huashan Hospital, 12 Wulumuqi Zhong Rd., Shanghai 200040, China [b]Beijing Tiantan Hospital, Beijing, China [c]Harbin Medical University First Hospital, Harbin, China [d]Xiangya Hospital of Centre-South University, Changsha, China [e]Beijing Army Hospital, Beijing, China [f]Peking University First Hospital, Beijing, China [g]West China Hospital, Sichuan University, Chengdu, China [h]Beijing Hospital, Beijing, China [i]No. 9 Hospital, Shanghai, China [j]Zhejiang Second Hospital, Hangzhou, China [k]Xi'an Medical University First Hospital, Xi'an, China [l]Renji Hospital, Shanghai, China [m]Zhongshan Hospital, Fudan University, Shanghai, China [n]Sun Yat-Sen University, Guangzhou, China [o]Peking Union Medical College Hospital, Beijing, China [p]Guangzhou Medical University Second Hospital, Guangzhou, China [q]Chongqing Medical University Second Hospital, Chongqing, China [r]Chongqing Medical University First Hospital, Chongqing, China [s]Zhejiang First Hospital, Hangzhou, China [t]Xuan Wu Hospital, Capital Medical University, Beijing, China [u]No. 6 Hospital, Shanghai, China [v]Tongji Hospital of Tongji University, Wuhan, China [w]Jilin Medical University First Hospital, Changchun, China
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关键词: Ischemia Prognosis Stroke Vascular

摘要:
Background/Aims: To measure the risk of vascular event occurrence among postischemic stroke patients in mainland China. Methods: In this multicenter prospective stroke registry study, we enrolled 1,951 patients diagnosed with acute ischemic stroke. Demographic data, prestroke risk factors, severity of neurological deficits and disability graded on the National Institutes of Health Stroke Scale (NIHSS), and modified Rankin Scale scores of each patient were measured and recorded. Patients were followed up regularly for 12 months after recruitment. Clinical endpoints were defined as occurrence of vascular events or death. Results: We detected 103 cases with nonfatal vascular events and 27 cases that died of vascular events. Cumulative incidences of total vascular events, cerebrovascular events, and coronary artery diseases were 7.2, 5.0, and 1.8%, respectively, at 12 months after the initial ischemic stroke. Concomitant atherosclerotic-thrombotic diseases (HR, 1.68; 95% CI, 1.14-2.43) and baseline NIHSS (HR, 1.07; 95% CI, 1.03-1.11) were found to be the best predictors for further occurrence of a vascular event. Antiplatelet therapy (HR, 0.52; 95% CI, 0.35-0.77) is associated with a lower risk of further vascular events. Conclusion: Our study provided valuable data on prognosis of acute ischemic stroke in Chinese patients. Copyright © 2009 S. Karger AG.

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出版当年[2009]版:
大类 | 3 区 医学
小类 | 3 区 公共卫生、环境卫生与职业卫生 4 区 临床神经病学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 公共卫生、环境卫生与职业卫生
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第一作者单位: [a]Institute of Neurology, Fudan University, Huashan Hospital, 12 Wulumuqi Zhong Rd., Shanghai 200040, China
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