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Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy

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资源类型：
Pubmed体系：
作者：
Yang, M[a,b] * ; Zhang, L[c,d] ; Bi, N[c] ; Ji, W[c] ; Tan, W[a,b] ; Zhao, L[c] ; Yu, D[a,b] ; Wu, C[a,b] ; Wang, L[c] ; Lin, D[a,b] ;
单位： [a]Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China [b]Key Laboratory for Carcinogenesis and Cancer Prevention, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China [c]Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China [d]Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
出处：
DOI： 10.1016/j.ijrobp.2009.12.042
ISSN：

关键词： Ataxia telangiectasia mutated protein Genetic polymorphism Lung cancer P53 Radiation-induced pneumonitis

摘要：
Purpose: Radiation-induced pneumonitis (RP) is the most common dose-limiting complication in lung cancer patients treated with radiotherapy. Accumulating evidence indicates that P53 and the ataxia telangiectasia-mutated protein (ATM) - dependent signaling response cascade play a crucial role in radiation-induced diseases. Consistent with this, our previous study showed that a functional genetic ATM polymorphism was associated with increased RP risk. Methods and Materials: To evaluate the role of genetic P53 polymorphism in RP, we analyzed the P53 Arg72Pro polymorphism in a cohort including 253 lung cancer patients receiving thoracic irradiation. Results: We found that the P53 72Arg/Arg genotype was associated with increased RP risk compared with the 72Pro/Pro genotype. Furthermore, the P53 Arg72Pro and ATM -111G>A polymorphisms display an additive combination effect in intensifying the risk of developing RP. The cross-validation test showed that 63.2% of RP cases can be identified by P53 and ATM genotypes. Conclusions: These results indicate that genetic polymorphisms in the ATM-P53 pathway influence susceptibility to RP and genotyping P53 and ATM polymorphisms might help to identify patients susceptible to developing RP when receiving radiotherapy. © 2011 Elsevier Inc.

语种：
外文
PubmedID：
第一作者：
第一作者单位： [a]Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China [b]Key Laboratory for Carcinogenesis and Cancer Prevention, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China
通讯作者：
通讯机构： [a]Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China [b]Key Laboratory for Carcinogenesis and Cancer Prevention, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China
推荐引用方式(GB/T 7714)：
Yang M,Zhang L,Bi N,et al.Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy[J].International journal of radiation oncology, biology, physics.2011,79(5):1402-7.doi:10.1016/j.ijrobp.2009.12.042.
APA：
Yang, M,Zhang, L,Bi, N,Ji, W,Tan, W...&Lin, D.(2011).Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy.International journal of radiation oncology, biology, physics,79,(5)
MLA：
Yang, M,et al."Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy".International journal of radiation oncology, biology, physics 79..5(2011):1402-7

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