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Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2

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单位: [a]Pharmazentrum Frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität, 60590 Frankfurt am Main, Germany [b]Institut für Klinische Neuroanatomie, Neuroscience Center, Goethe-Universität, 60590 Frankfurt am Main, Germany [c]AG Zelluläre Neurophysiologie, Technische Universität Darmstadt, 64287 Darmstadt, Germany [d]Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, 60528 Frankfurt am Main, Germany [e]Department of Traumatic Surgery, Tongji Hospital, Tongji Medical, College of Huazhong University of Science and Technology, Wuhan, China [f]Max-Planck-Institut für Medizinische Forschung, 69120 Heidelberg, Germany
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关键词: Glycine receptor alpha2 Knockout mice Nociception Pain behavior Spinal cord Zymosan

摘要:
Glycinergic synapses play a major role in shaping the activity of spinal cord neurons under normal conditions and during persistent pain. However, the role of different glycine receptor (GlyR) subtypes in pain processing has only begun to be unraveled. Here, we analysed whether the GlyR alpha2 subunit might be involved in the processing of acute or persistent pain. Real-time RT-PCR and in situ hybridization analyses revealed that GlyR alpha2 mRNA is enriched in the dorsal horn of the mouse spinal cord. Mice lacking GlyR alpha2 (Glra2 -/- mice) demonstrated a normal nociceptive behavior in models of acute pain and after peripheral nerve injury. However, mechanical hyperalgesia induced by peripheral injection of zymosan was significantly prolonged in Glra2 -/- mice as compared to wild-type littermates. We conclude that spinal GlyRs containing the alpha2 subunit exert a previously unrecognized role in the resolution of inflammatory pain. © 2011 Elsevier B.V.

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出版当年[2011]版:
大类 | 3 区 医学
小类 | 3 区 行为科学 3 区 神经科学
最新[2025]版:
大类 | 3 区 心理学
小类 | 3 区 行为科学 4 区 神经科学
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第一作者单位: [a]Pharmazentrum Frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität, 60590 Frankfurt am Main, Germany
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