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Prognostic value of TP/PD-ECGF and thrombocytosis in gastric carcinoma

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单位: [1]Xiangfan Univ, Xiangyang Cent Hosp, Dept Oncol, Xiangyang 441021, Peoples R China [2]Xiangfan Univ, Xiangyang Cent Hosp, Dept Urol, Xiangyang 441021, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, Wuhan 430030, Peoples R China [4]Xiangfan Univ, Xiangyang Cent Hosp, Dept Gastroenterol, Xiangyang 441021, Peoples R China
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关键词: Gastric carcinoma Thymidine phosphorylase Platelet-derived endothelial cell growth factor Thrombocytosis Prognosis

摘要:
Aim: Thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) is upregulated in several cancers and plays an important role in angiogenesis and invasion of solid tumors. In this study, we investigated the expression of TP/PD-ECGF in gastric carcinoma and its correlation with clinicopathological features and thrombocytosis, and also determined their prognostic significance. Methods: Ninety-eight tissue specimens were resected from patients with gastric carcinoma. The immunohistochemical staining was used for expression of TP/PD-ECGF, platelet counts (PLT) of all patients before surgery were recorded. Patients were divided into high and low TP/PD-ECGF expression groups. Correlations among TP/PD-ECGF expression, PLT and the clinicopathological features of the patients and their prognostic values were studied statistically. Results: Sixty-one cases of high TP/PD-ECGF expression (62%) and 37 cases of low TP/PD-ECGF expression (38%) were detected. There were 21 patients with thrombocytosis (21%). The results show that high TP/PD-ECGF expression was correlated positively with thrombocytosis (P = 0.046, r = 0.20). The 5-year overall survival rate was 46.0% in patients with low TP/PD-ECGF expression, whereas it was only 14.8% in patients with high TP/PD-ECGF expression (P = 0.000). The 5-year survival rate for patients with and without thrombocytosis were 9.5% and 31.2%, respectively, and there was a significant difference between them (P = 0.0001). The multivariate Cox regression analysis showed that high TP/PD-ECGF expression and thrombocytosis would play a role as independent prognostic factors in patients with gastric carcinoma. Conclusions: High TP/PD-ECGF expression and thrombocytosis can be regarded as valuable tools for predicting overall survival in patients with gastric carcinoma. (c) 2012 Elsevier Ltd. All rights reserved.

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出版当年[2011]版:
大类 | 3 区 医学
小类 | 2 区 外科 3 区 肿瘤学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 肿瘤学 2 区 外科
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出版当年[2010]版:
Q1 SURGERY Q2 ONCOLOGY
最新[2023]版:
Q1 SURGERY Q2 ONCOLOGY

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第一作者单位: [1]Xiangfan Univ, Xiangyang Cent Hosp, Dept Oncol, Xiangyang 441021, Peoples R China [*1]Xiangfan Univ, Xiangyang Cent Hosp, Dept Oncol, 39 Jingzhou St, Xiangyang 441021, Peoples R China
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通讯机构: [1]Xiangfan Univ, Xiangyang Cent Hosp, Dept Oncol, Xiangyang 441021, Peoples R China [*1]Xiangfan Univ, Xiangyang Cent Hosp, Dept Oncol, 39 Jingzhou St, Xiangyang 441021, Peoples R China
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