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Triterpenoids from the fruit of Schisandra glaucescens

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单位： [1]Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Fac Pharm, Tongji Med Coll, Wuhan 430030, Peoples R China [2]Huazhong Univ Sci & Technol, Dept Pharm, Tongji Hosp, Wuhan 430030, Peoples R China

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关键词： Schisandra glaucescens Diels Schisandraceae Triterpenoids Cytotoxicity

摘要：

Five new triterpenoids, named schiglausins P-T (1-5), together with twelve known analogues (6-17), were isolated from the fruit of Schisandra glaucescens Diels. Their structures were determined by various spectroscopic methods, including HRESIMS, 1D and 2D NMR spectra and CD experiment. Additionally, all these compounds were tested for their cytotoxicities against B16 mouse melanoma cell line. Compounds 8, 11, 14, and 15 exhibited moderate anti-proliferative effects against B16 cells with IC50 values ranging from 3.64 to 27.00 mu M. (C) 2016 Elsevier B.V. All rights reserved.

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出版当年[2015]版：

大类 | 3 区医学

小类 | 4 区药物化学 4 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

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出版当年[2014]版：

Q3 PHARMACOLOGY & PHARMACY Q3 CHEMISTRY, MEDICINAL

最新[2023]版：

Q3 CHEMISTRY, MEDICINAL Q3 PHARMACOLOGY & PHARMACY

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.345 出版当年[2014版] 2.466 出版当年五年平均 2.216 出版前一年[2013版] 2.408 出版后一年[2015版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Fac Pharm, Tongji Med Coll, Wuhan 430030, Peoples R China [2]Huazhong Univ Sci & Technol, Dept Pharm, Tongji Hosp, Wuhan 430030, Peoples R China

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