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Terrusnolides A-D, new butenolides with anti-inflammatory activities from an endophytic Aspergillus from Tripterygium wilfordii

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China [3]Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

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关键词： Endophytic fungus Aspergillus sp Butenolides Anti-inflammation

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Terrusnolides A -D (1-4), four butenolides were isolated from an endophytic Aspergillus from Tripterygium wilfordii. The structures of 1-4 were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculation. It is interesting that 1 was a butenolide derived by a triple decarboxylation, while 2-4 were the metabolites with 4-benzyl-3-phenyl-5H-furan-2-one motif possessing an isopentene group fused to the benzene ring. In vitro anti-inflammatory effects of these isolates were evaluated in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. 1-4 exhibited excellent inhibitory effects on the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO) in LPS-induced macrophages, comparable with the positive control (indomethacin). Those results indicated that, terrusnolides A- D might serve as new potential natural remedies for the treatment of inflammation.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

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出版当年[2016]版：

Q2 CHEMISTRY, MEDICINAL Q2 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q3 CHEMISTRY, MEDICINAL Q3 PHARMACOLOGY & PHARMACY

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.698 出版当年[2016版] 2.93 出版当年五年平均 2.408 出版前一年[2015版] 2.642 出版后一年[2017版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China

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