Chemical investigation of the plant endophytic fungus Pestalotiopsis sp. afforded two new butenolides, pestalolides B and C (1 and 2), two new diphenyl ethers, pestalotethers E and F (3 and 4), together with seven known compounds (5-11). Their structures were established by extensive spectroscopic analyses and the absolute configuration of 1 was further confirmed by ECD calculation. Structurally, compound 1 represents the first example of a new type of butenolide derivatives, bearing an unprecedented carbon scaffold having 13 carbon atoms. Compounds 1-4 were evaluated for the cytotoxic activities, and compound 1 showed remarkable inhibitory potency against human tumor HL60, U87MG, MDA-MB-231, and HEP-3B cell lines, with IC50, values of 1.42, 5.90, 5.90, and 4.29 mu M, respectively.
基金：
Innovative Research Groups of the National Natural Science Foundation of China [81721005]; National Natural Science Foundation of China [81573316, 21702067]; Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]; National natural Science Foundation for Distinguished Young Scholars [81725021]; China Postdoctoral Science Foundation [2017M610479, 2018T110777]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Beiye,Tong Qingyi,Lin Shuang,et al.Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp[J].PHYTOCHEMISTRY LETTERS.2019,29:186-189.doi:10.1016/j.phytol.2018.11.021.
APA：
Yang, Beiye,Tong, Qingyi,Lin, Shuang,Guo, Jieru,Zhang, Jinwen...&Zhang, Yonghui.(2019).Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp.PHYTOCHEMISTRY LETTERS,29,
MLA：
Yang, Beiye,et al."Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp".PHYTOCHEMISTRY LETTERS 29.(2019):186-189
