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WGCNA Co-Expression Network Analysis Reveals ILF3-AS1 Functions as a CeRNA to Regulate PTBP1 Expression by Sponging miR-29a in Gastric Cancer

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收录情况： ◇ SCIE

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单位： [1]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Oral & Maxillofacial & Head & Neck Oncol, Shanghai, Peoples R China [2]Fudan Univ, Childrens Hosp, Dept Neonatol, Shanghai, Peoples R China [3]Huazhong Univ Sci & Technol, Stomatol Ctr, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China

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关键词： gastric cancer WGCNA co-expression network miRNA prognosis

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Gastric cancer (GC) is one of the most common types of human cancers worldwide. However, the detail mechanisms underlying GC progression remained to be investigated. The present study identified 2823 differently expressed mRNAs and 441 differently expressed lncRNAs in GC. WGCNA was conducted to identify highly correlated lncRNAs and mRNAs. Bioinformatics analysis observed that these dysregulated lncRNAs were significantly associated with the regulation of angiogenesis, cell division, cell-cell adhesion, blood vessel development, adaptive immune response, gastric acid secretion, immune response. Co-expression analysis identified ILF3-AS1 was a key lncRNA involved in regulating GC progression. Loss of function assays showed that knockdown of ILF3-AS1 significantly suppressed GC cell proliferation and metastasis. Mechanically, the results indicate that ILF3-AS1 could enhance PTBP3 expression as an miR-29a sponge, thereby promoting the proliferation and metastasis of GC cells. Our work suggests that the ILF3-AS1/miR-29a/PTBP3 axis may be a potential target for the clinical diagnosis and treatment of GC.

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出版当年[2019]版：

大类 | 2 区生物

小类 | 3 区遗传学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区遗传学

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出版当年[2018]版：

Q2 GENETICS & HEREDITY

最新[2024]版：

Q2 GENETICS & HEREDITY

影响因子： 2.8 最新[2024版] 3.3 最新五年平均 3.517 出版当年[2018版] 0 出版当年五年平均 4.151 出版前一年[2017版] 3.26 出版后一年[2019版]

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第一作者单位： [1]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Oral & Maxillofacial & Head & Neck Oncol, Shanghai, Peoples R China

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