Two undescribed prenylated quinolinone alkaloids, aspoquinolones E and F, and three undescribed prenylated isoindolinone alkaloids aspernidines F-H, were isolated from the fungus Aspergillus nidulans. Their structures and configurations were elucidated based on spectroscopic analyses and ECD spectra. Aspoquinolones E and F possess a C-10 moiety with an unusual 2,2,4-trimethyl-3oxa-bicyclo[3.1.0]hexane unit, and aspernidines F-H own a C-15 side chain. These compounds were evaluated for cytotoxic activities against five human cancer cell lines, compounds 1 and 5 exhibited strong inhibitory activities against A-549 and SW-480 cells with IC50 values of 3.50 and 4.77 mu M, respectively.
基金：
Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]; National natural Science Foundation [81725021]; National Science and Technology Project of China [2018ZX09201001-001-003]; Innovative Research Groups of the National Natural Science Foundation of China [81721005]; Academic Frontier Youth Team of HUST; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST)
第一作者单位：[1]Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Qin,Chen Chunmei,He Yan,et al.Prenylated quinolinone alkaloids and prenylated isoindolinone alkaloids from the fungus Aspergillus nidulans[J].PHYTOCHEMISTRY.2020,169:doi:10.1016/j.phytochem.2019.112177.
APA：
Li, Qin,Chen, Chunmei,He, Yan,Wei, Mengsha,Cheng, Li...&Zhang, Yonghui.(2020).Prenylated quinolinone alkaloids and prenylated isoindolinone alkaloids from the fungus Aspergillus nidulans.PHYTOCHEMISTRY,169,
MLA：
Li, Qin,et al."Prenylated quinolinone alkaloids and prenylated isoindolinone alkaloids from the fungus Aspergillus nidulans".PHYTOCHEMISTRY 169.(2020)
