A new lignan, named 1,6-bis-(3-methoxy-4-hydroxyphenyl)hexane-1,6-dione (1), together with seven known compounds (2-8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. Their structures were elucidated based on extensive spectroscopic analyses. All isolates were evaluated for in vitro cytotoxic activity against human cancer cells of HepG2, A549, HeLa, and MCF-7. Among them, compound 8 showed significant cytotoxic activity on HepG2 and MCF-7 cells with IC50 values of 10.9 +/- 1.7 and 9.2 +/- 1.5 mu M, respectively.
基金：
General Project of Zhejiang Provincial Education Department [Y201840285]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Pharm, Tongji Med Coll, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wei Ying-Ying,Han Peng,Yue Jia-Qi,et al.Chemical Constituents from Acanthopanax senticosus and Their Cytotoxic Activities[J].CHEMISTRY OF NATURAL COMPOUNDS.2022,58(4):610-613.doi:10.1007/s10600-022-03753-3.
APA：
Wei, Ying-Ying,Han, Peng,Yue, Jia-Qi&Li, Fan.(2022).Chemical Constituents from Acanthopanax senticosus and Their Cytotoxic Activities.CHEMISTRY OF NATURAL COMPOUNDS,58,(4)
MLA：
Wei, Ying-Ying,et al."Chemical Constituents from Acanthopanax senticosus and Their Cytotoxic Activities".CHEMISTRY OF NATURAL COMPOUNDS 58..4(2022):610-613
