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Risk factors for severe bronchopulmonary dysplasia in a Chinese cohort of very preterm infants

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单位： [1]Department of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, [2]Xiamen Key Laboratory of Perinatal-Neonatal Infection, Xiamen Clinical Research Center for Perinatal Medicine, Xiamen, [3]Department of Neonatology (F. Wu), The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, [4]Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, [5]Department of Neonatology, Guiyang Maternal and Child Health Hospital, Guiyang Children's Hospital, Guiyang, [6]Department of Pediatrics , Peking University Third Hospital, Beijing, [7]Department of Neonatology, Children's Hospital of Fudan University, Shanghai, [8]Department of Neonatology , Guangdong Province Maternal and Children's Hospital, Guangzhou, [9]Department of Neonatology, General Hospital of Ningxia Medical University, Yinchuan, [10]Department of Neonatology, Children's Hospital of Hebei Province, Shijiazhuang, [11]Department of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, [12]Department of Neonatology, The First Hospital of Jilin University, Changchun, [13]Department of Neonatology, Quanzhou Maternity and Children's Hospital, Quanzhou, [14]Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, [15]Department of Neonatology, Liaocheng People's Hospital, Liaocheng, [16]Department of Neonatology, the Affiliate Hospital of Inner Mongolia Medical University, Hohhot, [17]Department of Neonatology, Suzhou Municipal Hospital, Suzhou, [18]Department of Neonatology , The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, and [19]Department of Neonatology, Chengdu Women' and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

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关键词： bronchopulmonary dysplasia nutrition risk factor very preterm infants very-low-birth-weight infants

摘要：

To examine the risk factors for severe bronchopulmonary dysplasia (BPD) in a cohort of very preterm infants (VPIs) in China, as BPD is common among VPIs and associated with a high mortality rate.In this multicenter retrospective study, medical records from infants with BPD born at gestation age (GA) of <32 weeks with birth weight (BW) of <1,500 grams (g) in 7 regions of China were included. The cohort was stratified into different BPD severity groups based on their fraction of inspired oxygen requirement at a modified GA of 36 weeks or post discharge. Risk factors were identified using logistic regression analysis.A significant inverse correlation was revealed between BPD severity and both GA and BW (p<0.001). Independent risk factors for severe BPD (sBPD) were identified as invasive mechanical ventilation (≥7d), multiple blood transfusion (≥3), nosocomial infection (NI), hemodynamically significant patent ductus arteriosus (hsPDA), delayed initiation of enteral nutrition, and longer time to achieve total caloric intake of 110 kcal/kg. Conversely, administration of antenatal steroids was associated with reduced risk of sBPD.Our study not only reaffirmed the established risk factors of low GA and BW for sBPD in VPIs, but also identified additional, potentially modifiable risk factors. Further research is warranted to explore whether intervention in these modifiable factors might reduce the risk of sBPD.Clinical Trial Reg. No.: ChiCTR1900023418.Copyright: © Saudi Medical Journal.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区医学：内科

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：内科

第一作者：

第一作者单位： [1]Department of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, [2]Xiamen Key Laboratory of Perinatal-Neonatal Infection, Xiamen Clinical Research Center for Perinatal Medicine, Xiamen,

通讯作者：

通讯机构： [1]Department of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, [2]Xiamen Key Laboratory of Perinatal-Neonatal Infection, Xiamen Clinical Research Center for Perinatal Medicine, Xiamen,

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Risk factors for severe bronchopulmonary dysplasia in a Chinese cohort of very preterm infants

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