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Thrombolysis increases the risk of persistent headache attributed to ischemic stroke: A prospective observational study

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单位： [1]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [2]Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan, China. [3]Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA. [4]Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. [5]Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

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关键词： intravenous thrombolysis ischemia persistent headache attributed to past ischemic stroke

摘要：

Persistent headache attributed to ischemic stroke (PHPIS) is increasingly acknowledged and was added to the 2018 ICHD-3. Intravenous thrombolysis (IVT) is a common treatment for acute ischemic stroke. It remains unknown whether this treatment influences the occurrence of a persistent poststroke headache. We aimed to describe the incidence and clinical characteristics of persistent headaches occurring after acute ischemic stroke in patients with or without IVT and explore the risk factors.A prospective observational study was performed between the 234 individuals who received IVT and 226 individuals without IVT in 5 stroke units from Wuhan, China. Subjects were followed for 6 months after stroke via a structured questionnaire.Age, gender, vascular risk factors, and infarct location/ circulation distribution did not differ between the groups, although IVT group had higher initial NIHSS scores. At the end of the follow-up, 12.0% (55/460) of subjects reported persistent headaches after ischemic stroke. The prevalence of persistent headache was significantly higher in the IVT group than non-IVT group (15.4% vs. 8.4%, p = .021). Patients with younger age (p = .033; OR 0.97; 95% CI 0.939-0.997), female sex (p = .007; OR 2.40; 95% CI 1.269-4.520), posterior circulation infarct (p = .024; OR 2.19; 95% CI 1.110-4.311), and IVT (p = .005; OR 2.51; 95% CI 1.313-4.782) were more likely to develop persistent headache after ischemic stroke.The potential influence of IVT should be considered when assessing persistent poststroke headache. Future studies will investigate the underlying mechanisms.© 2024 The Authors. Brain and Behavior published by Wiley Periodicals LLC.

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出版当年[2023]版：

大类 | 3 区心理学

小类 | 4 区行为科学 4 区神经科学

最新[2025]版：

大类 | 3 区心理学

小类 | 3 区行为科学 4 区神经科学

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出版当年[2022]版：

Q2 BEHAVIORAL SCIENCES Q3 NEUROSCIENCES

最新[2023]版：

Q2 BEHAVIORAL SCIENCES Q3 NEUROSCIENCES

影响因子： 2.6 最新[2023版] 3.1 最新五年平均 3.1 出版当年[2022版] 3.1 出版当年五年平均 3.405 出版前一年[2021版] 2.6 出版后一年[2023版]

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第一作者单位： [1]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

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通讯作者：

通讯机构： [1]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [2]Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan, China. [*1]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China

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Thrombolysis increases the risk of persistent headache attributed to ischemic stroke: A prospective observational study

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