Since mass effect and secondary brain injuries persist in the pathogenesis of intracerebral hemorrhage, hematoma evacuation within a limited time is reasonable. However, it is complex to define an accurate therapeutic time window (TTW) for hematoma evacuation. In this review, studies about TTW were dis-cussed from four aspects: histopathology, molecular pathophysiology, neuroimaging and clinical out-comes. Animal experiments indicated that 6-12 h is the pathophysiological TTW of minimally invasive surgery. Clinical trials suggested that there is a correlation between TTW and clinical outcomes, while the exact TTW is still unclear due to lack of sufficient clinical studies, which deserves further investigation.(c) 2020 International Hemorrhagic Stroke Association. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creati-vecommons.org/licenses/by-nc-nd/4.0/).
基金：
National Natural Science Founda- tion of China [81873750]; Frontier special Project of applied Foundation of Wuhan science and Technology Bureau [2018060401011316]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Neurol,Wuhan 430030,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Guo Guangyu,Guo Wenliang,Feng Yangyang,et al.Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage[J].BRAIN HEMORRHAGES.2020,1(3):158-160.doi:10.1016/j.hest.2020.07.002.
APA：
Guo, Guangyu,Guo, Wenliang,Feng, Yangyang,Deng, Hong,Zhang, Ping...&Tang, Zhouping.(2020).Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage.BRAIN HEMORRHAGES,1,(3)
MLA：
Guo, Guangyu,et al."Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage".BRAIN HEMORRHAGES 1..3(2020):158-160
