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WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata

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收录情况： ◇ SCIE

作者：
Gu Zhichao[1] * ; Liu Jiaying[1] * ; Qin Lei[1] ; Zhang Yong[1] ; Cui Wenya[1] ; Huang Huayu[1] ; Liu Lian[1] ; Cao Yuchun[1,*1] ; Zhang Huafeng[2,3,*2] ;
单位： [1]Department of Dermatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]Institute of Pathology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [3]Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
出处：
DOI： 10.1016/j.jdermsci.2023.07.004
ISSN：

关键词： Condylomata acuminata Antiviral responses M6 A modification WT1-associated protein (WTAP) IFNE

摘要：
IFN-ε is essential in combating viral infections, particularly in epithelial cells and protected mucosal tissues. Its protective effects have been demonstrated against HSV2, Zika virus, HIV and SARS-COV2. However, the specific expression and role of IFN-ε in skin keratinocytes and HPV infection are still not fully understood and require further investigation.In this study, we aimed to investigate the functions and expression mechanism of IFN-ε in keratinocytes during HPV infection and the progression of condyloma acuminata.Keratinocytes isolated from biopsied CA warts and normal skins samples were analyzed by MeRIP-seq analysis. IFN-ε and WTAP in CA warts and normal skins were analyzed by immunostaining and qPCR.In this study, we identified IFN-ɛ was markedly upregulated in CA warts and HPV-infected keratinocytes. IFN-ɛ expression also showed negatively correlation with the size of CA warts (R=-0.4646, P = 0.009). IFN-ɛ suppressed the susceptibility of HPV infection directly. m6A analysis reveals WTAP is a key m6A writer promoting the m6A modification of IFNE mRNA.Our research suggests that IFN-ɛ is an important Type I IFN cytokine involved in the development of genital warts. Furthermore, we found that HPV infection affects the m6A modifications of IFNE through a mechanism dependent on WTAP. This study provides insights into the innate immune response of the host to HPV infection and may contribute to the development of future strategies for regulating innate immunity to treat genital warts.Copyright © 2023 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (No. 82002183 and 81974308) and Knowledge Innovation Program of Wuhan-Shuguang Project.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 2 区 皮肤病学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 皮肤病学
JCR分区：
出版当年[2021]版：
Q1 DERMATOLOGY
最新[2024]版：
Q1 DERMATOLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Dermatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Dermatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]Institute of Pathology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [3]Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [*1]Department of Dermatology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [*2]Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,China.
推荐引用方式(GB/T 7714)：
Gu Zhichao,Liu Jiaying,Qin Lei,et al.WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata[J].JOURNAL OF DERMATOLOGICAL SCIENCE.2023,111(2):43-51.doi:10.1016/j.jdermsci.2023.07.004.
APA：
Gu Zhichao,Liu Jiaying,Qin Lei,Zhang Yong,Cui Wenya...&Zhang Huafeng.(2023).WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata.JOURNAL OF DERMATOLOGICAL SCIENCE,111,(2)
MLA：
Gu Zhichao,et al."WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata".JOURNAL OF DERMATOLOGICAL SCIENCE 111..2(2023):43-51

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