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A novel urokinase plasminogen activator receptor-targeted peptide-based probe for in-vivo molecular imaging of glioblastoma

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收录情况： ◇ SCIE

作者：
Han Yunfeng[1,2] * ; Tu Le[3] * ; Zhang Yongxue[2] ; Xu Liying[4] ; Sun Ziyan[5,*1] ;
单位： [1]Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. [2]Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. [3]Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University. [4]Department of Radiology, Zhongnan Hospital of Wuhan University. [5]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出处：
DOI： 10.1097/MNM.0000000000001644
ISSN：

关键词： glioma peptide-based imaging probe positron emission computed tomography imaging U87MG urokinase plasminogen activator receptor

摘要：
The urokinase plasminogen activator receptor (uPAR) is a promising biomarker for cancer diagnosis and therapy. We herein fabricated a new type of uPAR-targeted imaging probe Al18F-NOTA-VC and preliminarily evaluated its potential application in PET imaging of the glioma model in vivo.Peptide VC was synthesized and identified by MALDI-TOF-MS. The IC50 between VC/precursor NOTA-VC and uPAR was then determined before the synthesis and purification of Al18F-NOTA-VC, followed by further studies of in-vitro properties of Al18F-NOTA-VC. Meanwhile, the AE105-based probe followed a similar procedure in-vitro test. Finally, the PET imaging properties, including uPAR-targeting ability and the metabolism of Al18F-NOTA-VC, were investigated.The VC and NOTA-VC were obtained successfully and demonstrated a good affinity with uPAR. Followed by Al18F labeling successfully, excellent properties, including the serum stability, water solubility, and specificity of Al18F-NOTA-VC, were obtained in-vitro test compared with AE105 based probe. An excellent tumor uptake and renal excretion data of Al18F-NOTA-VC were acquired from in-vivo U87MG tumor model PET imaging, consistent with the subsequent biodistribution study.In addition to the excellent specificity and high tumor/normal tissue contrast for uPAR-targeted PET imaging of U87MG tumor, Al18F-NOTA-VC possessed promising clearance ability by renal system route. These excellent properties facilitated Al18F-NOTA-VC to be a promising imaging agent for uPAR high-expressing tumors and, thus, provided a paradigm for developing peptide-based probes for uPAR-associated disease diagnosis.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

基金：
This study was supported by the Hubei Province Key Laboratory of Molecular Imaging Grant (No. 2020fzyx011).
语种：
外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 医学
小类 | 4 区 核医学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 核医学
JCR分区：
出版当年[2021]版：
Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2024]版：
Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2024版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. [2]Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.
共同第一作者：
通讯作者：
通讯机构： [5]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [*1]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China
推荐引用方式(GB/T 7714)：
Han Yunfeng,Tu Le,Zhang Yongxue,et al.A novel urokinase plasminogen activator receptor-targeted peptide-based probe for in-vivo molecular imaging of glioblastoma[J].NUCLEAR MEDICINE COMMUNICATIONS.2023,44(2):142-149.doi:10.1097/MNM.0000000000001644.
APA：
Han Yunfeng,Tu Le,Zhang Yongxue,Xu Liying&Sun Ziyan.(2023).A novel urokinase plasminogen activator receptor-targeted peptide-based probe for in-vivo molecular imaging of glioblastoma.NUCLEAR MEDICINE COMMUNICATIONS,44,(2)
MLA：
Han Yunfeng,et al."A novel urokinase plasminogen activator receptor-targeted peptide-based probe for in-vivo molecular imaging of glioblastoma".NUCLEAR MEDICINE COMMUNICATIONS 44..2(2023):142-149

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