A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer
研究单位：[1]Eli Lilly and Company[2],Korea, Republic of,31151[3],Korea, Republic of,21565[4],Korea, Republic of,03080[5],Korea, Republic of,03181[6],Korea, Republic of,05505[7],Korea, Republic of,06273[8],Korea, Republic of,06351[9],Spain,08035[10],Spain,08041[11]Ironwood Cancer & Research Centers,Chandler,Arizona,United States,85224[12]Banner MD Anderson Cancer Center,Gilbert,Arizona,United States,85234[13]Marin Cancer Care,Greenbrae,California,United States,94904[14]University of California, Davis - Health Systems,Sacramento,California,United States,95817[15]Sharp Memorial Hospital,San Diego,California,United States,92123[16]Banner MD Anderson Cancer Center at North Colorado Medical Center,Greeley,Colorado,United States,80631[17]Rocky Mountain Cancer Center,Lone Tree,Colorado,United States,80124[18]Banner MD Anderson Cancer Center at McKee Medical Center,Loveland,Colorado,United States,80538[19]Clermont Oncology Center,Clermont,Florida,United States,34711[20]Univ of Florida School of Medicine,Gainesville,Florida,United States,32610[21]Mid Florida Hematology and Oncology Center,Orange City,Florida,United States,32763[22]Florida Cancer Specialists,Saint Petersburg,Florida,United States,33705[23]Florida Cancer Specialists,Sarasota,Florida,United States,34232[24]Florida Cancer Specialists,West Palm Beach,Florida,United States,33401[25]Kaiser Permanente Moanalua Medical Center,Honolulu,Hawaii,United States,96819[26]Rush University Medical Center,Chicago,Illinois,United States,60612[27]University of Illinois at Chicago,Chicago,Illinois,United States,60612[28]University of Chi Med Center,Chicago,Illinois,United States,60637[29]NorthShore University HealthSystem - Evanston Hospital,Evanston,Illinois,United States,60201[30]IU Health Ball Memorial Hospital, Inc.,Muncie,Indiana,United States,47303[31]The University of Louisville, James Graham Brown Cancer Center,Louisville,Kentucky,United States,40202[32]Minnesota Oncology/Hematology PA,Coon Rapids,Minnesota,United States,55433[33]Jackson Oncology Associates, PLLC,Jackson,Mississippi,United States,39202[34]Care Access - Clifton,Clifton,New Jersey,United States,07013[35]Rutgers Cancer Institute of New Jersey,New Brunswick,New Jersey,United States,08901[36]The Valley Hospital,Ridgewood,New Jersey,United States,07450[37]Broome Oncology,Binghamton,New York,United States,13905[38]Columbia University Medical Center,New York,New York,United States,10032[39]Memorial Sloan Kettering Cancer Center,New York,New York,United States,10065[40]University of North Carolina Medical Center,Chapel Hill,North Carolina,United States,27599[41]Aultman Hospital - Timken Family Cancer Center,Canton,Ohio,United States,44710[42]The Mark H Zangmeister Cancer Center,Columbus,Ohio,United States,43219[43]Mercy Health - St. Vincent Medical Center,Toledo,Ohio,United States,43608[44]Willamette Valley Cancer Institute & Research Ctr.,Eugene,Oregon,United States,97401[45]Avera Cancer Institute,Sioux Falls,South Dakota,United States,57105[46]Sarah Cannon Research Institute SCRI,Nashville,Tennessee,United States,37203[47]Texas Oncology - Austin Central,Austin,Texas,United States,78731[48]Texas Oncology - Carrollton,Carrollton,Texas,United States,75010[49]Texas Oncology - Methodist Charlton Cancer Center,Dallas,Texas,United States,75203[50]Texas Oncology - Medical City Dallas,Dallas,Texas,United States,75230[51]USO - Texas Oncology, P. A.,Dallas,Texas,United States,75231[52]Texas Oncology-Baylor Charles A. Sammons Cancer Center,Dallas,Texas,United States,75246[53]Texas Oncology - Denison,Denison,Texas,United States,75020[54]Texas Oncology Denton,Denton,Texas,United States,76201[55]Texas Oncology Fort Worth,Fort Worth,Texas,United States,76104[56]Texas Oncology - Willowbrook,Houston,Texas,United States,77070[57]Texas Oncology - McKinney,McKinney,Texas,United States,75071[58]Texas Oncology - Paris,Paris,Texas,United States,75460[59]Texas Oncology - San Antonio Medical Center,San Antonio,Texas,United States,78240[60]Texas Oncology - The Woodlands,The Woodlands,Texas,United States,77380[61]US Oncology,The Woodlands,Texas,United States,77380[62]Utah Cancer Specialists,Salt Lake City,Utah,United States,84106[63]University of Vermont Medical Center,Burlington,Vermont,United States,05401[64]Blue Ridge Cancer Care,Salem,Virginia,United States,24153[65]Fundación CENIT para la Investigación en Neurociencias,Caba,BA,Argentina,C1125ABD[66]Instituto de Investigaciones Clínicas Mar del Plata,Mar del Plata,Buenos Aires,Argentina,7600[67]CIPREC,Buenos Aires,Ciudad Autónoma De Buenos Aire,Argentina,C1061AAS[68]Clinica Viedma S. A,Viedma,Río Negro,Argentina,R8500ACE[69]Instituto Argentino de Diagnóstico y Tratamiento (IADT),Buenos Aires,Argentina,C1122AAL[70]Cent Priva Especiali Médicas Ambulatorias Inve Clin CEMAIC,Cordoba,Argentina,X5008HHW[71]Instituto San Marcos,San Juan,Argentina,5400[72]Sanatorio Norte,Santiago del Estero,Argentina,4200[73]St Vincent's Hospital,Darlinghurst,New South Wales,Australia,2010[74]Princess Alexandra Hospital,Brisbane,Queensland,Australia,4102[75]Cancer Research SA,Adelaide,South Australia,Australia,5000[76]Box Hill Hospital,Box Hill,Victoria,Australia,3128[77]Maroondah Hospital,Melbourne,Victoria,Australia,3135[78]Medizinische Universitaet Graz,Graz,Steiermark,Austria,8036[79]Private Practice - Dr. Hubalek,Schwaz,Tirol,Austria,6130[80]Medizinische Universität Wien,Vienna,Wien,Austria,1090[81]Universitätsklinikum Salzburg,Salzburg,Austria,5020[82]Imelda General Hospital,Bonheiden,Antwerpen,Belgium,2820[83]UZ Brussel,Brussels,Bruxelles-Capitale, Région De,Belgium,1090[84]UZ Gent,Gent,Oost-Vlaanderen,Belgium,9000[85]VITAZ,Sint-Niklaas,Oost-Vlaanderen,Belgium,B-9100[86]AZ Groeninge Campus Kennedylaan,Kortrijk,West-Vlaanderen,Belgium,8500[87]Institut Jules Bordet,Brussels-Capital,Belgium,1070[88]Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg,Leuven,Belgium,3000[89]CHU UCL Namur/Site Sainte Elisabeth,Namur,Belgium,5000[90]Hospital de Cancer de Londrina,Londrina,Paraná,Brazil,86015-520[91]Faculdade de Medicina do ABC,Santo Andre,SP,Brazil,09060-650[92]Icesp - Instituto Do Câncer Do Estado de São Paulo,São Paulo,Brazil,01246-000[93]Clínica de Pesquisas e Centro de Estudos em Oncologia Ginecológica e Mamária Ltda,São Paulo,Brazil,01317-000[94]IBCC - Instituto Brasileiro de Controle do Câncer,São Paulo,Brazil,04014-002[95]The First Afflilated Hospital of Bengbu Medical College,Bengbu,Anhui,China,233004[96]Beijing Hospital,Beijing,Beijing,China,100005[97]The Fifth Medical Center of PLA General Hospital,Beijing,Beijing,China,100071[98]Beijing Cancer hospital,Beijing,Beijing,China,100142[99]Fujian Provincial Cancer Hospital,Fuzhou,Fujian,China,350014[100]Sun Yat-Sen University Cancer Centre,Guangzhou,Guangdong,China,511400[101]Harbin Medical University Cancer Hospital,Harbin,Heilongjiang,China,150081[102]The First Affiliated Hospital of Henan University of Science &Technology,Luoyang,Henan,China,471003[103]Renmin Hospital of Wuhan University,Wuhan,Hubei,China,430060[104]Hubei Cancer Hospital,Wuhan,Hubei,China,430079[105]The First People's Hospital of Changde City,Changde,Hunan,China,415003[106]Hunan Provincial People's Hospital,ChangSha,Hunan,China,410005[107]Xiangya Hospital Central South University,Changsha,Hunan,China,410008[108]Hunan Cancer Hospital,Changsha,Hunan,China,421000[109]The Third Hospital of Nanchang,Nanchang,Jiangxi,China,330009[110]The Second Hospital of Jilin University,Changchun,Jilin,China,130000[111]The First Hospital of Jilin University,Changchun,Jilin,China,130021[112]Jiangsu Province Hospital,Nanjing,Nanjing,China,210029[113]The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,China,710061[114]Jinan Central Hospital,Jinan,Shandong,China,250013[115]Yantai Yuhuangding Hospital,Yantai,Shandong,China,264000[116]Tianjin Medical University Cancer Institute and Hospital,Tianjin,Tianjin,China[117]The First Affiliated Hospital, Zhejiang University,Hangzhou,Zhejiang,China,310003[118]Sir Run Run Shaw Hospital,Hangzhou,Zhejiang,China,310016[119]Zhejiang Cancer Hospital,Hangzhou,Zhejiang,China,310022[120]Hwa Mei Hospital University of Chinese Academy of Sciences,Ningbo,Zhejiang,China,315010[121]Ningbo Medical Center,Ningbo,Zhejiang,China,315041[122]Sichuan Cancer Hospital,Chengdu,China,610041[123]Jining Medical University - Affiliated Hospital,Jining,China,272029[124]Wu Han Tongji Hospital,Wuhan,China,430030[125]Thomayerova nemocnice,Praha,Praha 4 - Krč,Czechia,14059[126]Nemocnice Na Bulovce,Prague,Praha 8,Czechia,180 81[127]Nemocnice Horovice,Horovice,Czechia,268 01[128]Fakultni nemocnice Kralovske Vinohrady,Praha 10,Czechia,100 34[129]Oblastní nemocnice Příbram, a.s.,Pribram,Czechia,261 01[130]Institut de cancérologie Strasbourg Europe (ICANS),Strasbourg,Alsace,France,67033[131]CHU Besançon,Besançon,Doubs,France,25000[132]Centre de Cancérologie du Grand Montpellier,Montpellier,Languedoc-Roussillon,France,34070[133]Institut de Cancérologie de Lorraine Alexis Vautrin,Vandoeuvre-lès-Nancy,Lorraine,France,54519[134]Centre Hospitalier de la Côte Basque,Bayonne,Pyrénées-Atlantiques,France,64109[135]Polyclinique De Blois,La Chaussee Saint Victor,France,41260[136]Clinique Victor Hugo - Centre Jean Bernard,Le Mans,France,72000[137]Institut Curie,Paris,France,75248[138]Institut Curie,Saint-Cloud,Île-de-France,France,92210[139]Onkologische Schwerpunktpraxis Heidelberg, Dr. med. Andreas Karcher, Dr. med. Daniel Debatin, Dr. med. Stefan Fuxius,Heidelberg,Baden-Württemberg,Germany,69115[140]Klinikum Ludwigsburg,Ludwigsburg,Baden-Württemberg,Germany,71640[141]Onkologiezentrum Donauwörth,Donauwörth,Bayern,Germany,86609[142]Universitätsklinikum Erlangen,Erlangen,Bayern,Germany,91054[143]Klinikum der Ludwig-Maximilians-Universitaet Muenchen,München,Bayern,Germany,80336[144]Agaplesion Markus Krankenhaus,Frankfurt,Hessen,Germany,60431[145]Gynäkologisch-Onkologische Praxis am Pelikanplatz,Hannover,Niedersachsen,Germany,30177[146]Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung,Essen,Nordrhein-Westfalen,Germany,45136[147]Evangelisches Krankenhaus Bethesda Mönchengladbach,Mönchengladbach,Nordrhein-Westfalen,Germany,41061[148]Universitaetsklinikum Schleswig-Holstein Campus Kiel,Kiel,Schleswig-Holstein,Germany,24105[149]Gynaekologisches Zentrum Bonn,Bonn,Germany,53111[150]Agios Savvas Regional Cancer Hospital,Athens,Attikí,Greece,115 22[151]Alexandra General Hospital of Athens,Athens,Attikí,Greece,11528[152]General Oncology Hospital of Kifissia "Agioi Anargiroi",Nea Kifissia,Attikí,Greece,145 64[153]"
University General Hospital of Heraklion,Heraklion,Irakleío,Greece,715 00[154]Euromedica General Clinic of Thessaloniki,Thessaloniki,Thessaloníki,Greece,546 45[155]European Interbalkan Medical Center,Thessaloniki,Thessaloníki,Greece,570 01[156]University General Hospital of Larissa,Larissa,Thessalía,Greece,41110[157]General Hospital of Thessaloniki Papageorgiou,Thessaloniki,Greece,56403[158]Maulana Azad Medical College,New Delhi,Delhi,India,110002[159]Medstar Speciality Hospital,Bangalore,Karnataka,India,560092[160]HCG-Bangalore,Bengaluru,Karnataka,India,560027[161]Regional Cancer Centre - Thiruvananthapuram,Thiruvananthapuram,Kerala,India,695011[162]HCG Cancer Centre,Mumbai,Maharashtra,India,400092[163]Government Medical College And Hospital - Nagpur,Nagpur,Maharashtra,India,440003[164]Rashtrasant Tukdoji Regional Cancer Hospital,Nagpur,Maharashtra,India,440027[165]HCG Manavata Cancer Centre,Nashik,Maharashtra,India,422001[166]Deenanath Mangeshkar Hospital & Research Centre,Pune,Maharashtra,India,411004[167]Lifepoint Multispeciality Hospital,Pune,Maharashtra,India,411057[168]Yashoda Hospitals,Hyderabad,Telangana,India,500082[169]University of Naples Federico II,Naples,Campania,Italy,80100[170]Istituto Nazionale Tumori IRCCS Fondazione Pascale,Napoli,Campania,Italy,80131[171]Cro-Irccs,Aviano,Friuli-Venezia Giulia,Italy,33081[172]Azienda Ospedaliera Universitaria Careggi,Firenze,Toscana,Italy,50134[173]Ospedale San Martino,Genova,Italy,16132[174]Istituto Europeo di Oncologia IRCCS,Milano,Italy,20141[175]Istituto Oncologico Veneto IRCCS,Padova,Italy,35128[176]Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore,Roma,Italy,00168[177]Nagoya University Hospital,Nagoya,Aichi,Japan,466-8560[178]Chiba cancer center,Chiba-shi,Chiba,Japan,260-8717[179]National Hospital Organization Shikoku Cancer Center,Matsuyama,Ehime,Japan,791-0280[180]Kurume General Hospital,Kurume,Fukuoka,Japan,830-0013[181]Gunma Prefectural Cancer Center,Ota,Gunma,Japan,373-0828[182]National Hospital Organization Hokkaido Cancer Center,Sapporo,Hokkaido,Japan,003-0804[183]Hyogo Cancer Center,Akashi,Hyogo,Japan,673-8558[184]Shinko Hospital,Kobe,Hyogo,Japan,651-0072[185]University of tsukuba hospital,Tsukuba-shi,Ibaragi,Japan,305-8576[186]Tsuchiura Kyodo General Hospital,Tsuchiura,Ibaraki,Japan,300-0028[187]St. Marianna University Hospital,Kawasaki,Kanagawa,Japan,216-8511[188]Kanagawa cancer center,Yokohama,Kanagawa,Japan,241-8515[189]Nagano Municipal Hospital,Tomitake,Nagano,Japan,381-8551[190]Niigata Cancer Center Hospital,Niigata-shi,Niigata,Japan,951-8566[191]Juntendo University Hospital,Bunkyo-ku,Tokyo,Japan,113-8431[192]Showa University Hospital,Shinagawa,Tokyo,Japan,142-8555[193]National Hospital Organization Kyushu Cancer Center,Fukuoka,Japan,811-1395[194]Hiroshima City Hospital,Hiroshima,Japan,730-8518[195]Sagara Hospital,Kagoshima,Japan,892-0833[196]Kumamoto Shinto General Hospital,Kumamoto,Japan,862-8655[197]Osaka International Cancer Institute,Osaka,Japan,541-8567[198]Shizuoka Prefectural General Hospital,Shizuoka,Japan,420-0881[199]Severance Hospital, Yonsei University Health System,Seoul,Korea,Korea, Republic of,03722[200]Ajou University Hospital,Suwon-si,Kyǒnggi-do,Korea, Republic of,16499[201]Yeungnam Univeristy Medical Center,Gyeongsan-si,Kyǒngsangbuk-do,Korea, Republic of,42415[202]Dong-A University Hospital,Busan,Pusan-Kwangyǒkshi,Korea, Republic of,49201[203]Kyungpook National University Chilgok Hospital,Daegu,Taegu-Kwangyǒkshi,Korea, Republic of,41404[204]Centro de Investigación Clínica de Alta Especialidad,Torreón,Coahuila,Mexico,27010[205]Grupo Medico Camino Sc,Mexico City,Distrito Federal,Mexico,03310[206]Christus Muguerza Clinica Vidriera (Christus Muguerza Sistemas Hospitalarios S.A. de C.V.),Monterrey Nuevo León, C.P.,Monterrey,Mexico,64570[207]COI Centro Oncológico Intl. S.A.P.I. de C.V._ S.F.,Paso De Las Lomas,MX,Mexico,01330[208]Private Practice - Dr. Joaquin Reinoso,Monterrey,Nuevo León,Mexico,64320[209]Centro Medico Zambrano Hellion,San Pedro Garza Garcia,Nuevo León,Mexico,66278[210]Unidad de Investigación en Salud,Chihuahua,Mexico,31203[211]Oaxaca Site Management Organization,Oaxaca,Mexico,68000[212]Unidad Médica Onco-hematológica,Puebla,Mexico,72424[213]Medische Centrum Leeuwarden,Leeuwarden,Fryslân,Netherlands,8934 AD[214]Maastricht UMC+,Maastricht,Limburg,Netherlands,6229 HX[215]Haga Ziekenhuis locatie Leyweg,Den Haag,Zuid-Holland,Netherlands,2545 AA[216]SHI Kaluga Regional Hospital,Kaluga,Kalužskaja Oblast,Russian Federation,248007[217]N.N.Petrov Research Institute of Oncology,St. Petersburg,Peterburg,Russian Federation,197758[218]Volgograd Regional Clinical Cancer Clinic No.1,Volgograd,Volgogradskaya Oblast',Russian Federation,400138[219]Hospital Universitari Arnau de Vilanova,Lleida,Cataluña,Spain,25198[220]Hospital Universitario Ramón y Cajal,Madrid,Madrid, Comunidad De,Spain,28034[221]Hospital Universitario de Canarias,La Laguna,Santa Cruz De Tenerife,Spain,38320[222]Hospital Universitario San Cecilio,Granada,Spain,18016[223]Hospital Clinico San Carlos,Madrid,Spain,28040[224]Hospital Universitario Virgen Macarena,Sevilla,Spain,41009[225]Hospital Universitario Virgen Del Rocio,Sevilla,Spain,41013[226]Hospital Clínico Universitario de Valencia,Valencia,Spain,46010[227]Hospital Quirón Salud Valencia,Valencia,Spain,46010[228]Chi Mei Hospital - Liouying Branch,Tainan City,Tainan,Taiwan,73657[229]Taichung Veterans General Hospital,Taichung,Taiwan,40705, ROC[230]National Cheng Kung University Hospital,Tainan,Taiwan,704[231]National Taiwan University Hospital,Taipei,Taiwan,10002[232]Koo Foundation Sun Yat-Sen Cancer Center,Taipei,Taiwan,112[233]Acibadem Altunizade Hospital,Üsküdar / Stanbul,İstanbul,Turkey[234]Ege University Medicine of Faculty,Bornova,İzmir,Turkey,35100[235]Baskent University Dr. Turgut Noyan Research and Training Center,Adana,Turkey,01250[236]University of Health Sciences,Gulhane School of Medicine,Ankara,Turkey,06010[237]Hacettepe Universitesi,Ankara,Turkey,06230[238]Memorial Ankara Hastanesi,Ankara,Turkey,06520[239]Ankara City Hospital,Ankara,Turkey,06800[240]Abdurrahman Yurtaslan Ankara Oncology, education and Research Hospital,Ankara,Turkey[241]Akdeniz University Medical Faculty,Antalya,Turkey,07059[242]Dicle Üniversitesi,Diyarbakir,Turkey,21200[243]Trakya University,Edirne,Turkey,22030[244]Medipol Mega University Hospital,Istanbul,Turkey,34214[245]Acıbadem Maslak Hastanesi,İstanbul,Turkey,34457[246]TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi,Istanbul,Turkey,34722[247]İnönü Üniversitesi Turgut Özal Tıp Merkezi,Malatya,Turkey,44280[248]Mersin University,Mersin,Turkey,33343[249]MI Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council[250]Chemotherapy Department,Kryvyi Rih,Dnipropetrovska Oblast,Ukraine,50048[251]CNPE "Regional Center of Oncology",Kharkiv,Kharkivska Oblast,Ukraine,61070[252]"
Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council,Odesa,Odeska Oblast,Ukraine,65025[253]Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council",Vinnytsia,Vinnytska Oblast,Ukraine,21029[254]"
Municipal Enterprise "Volyn Regional Medical Oncology Centre" of the Volyn Regional Council,Lutsk,Volynska Oblast,Ukraine,43018[255]"
Uzhgorod Central City Clinical Hospital,Uzhhorod,Zakarpatska Oblast,Ukraine,88000
The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy, and how well imlunestrant with abemaciclib work compared to imlunestrant in participants with breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Participants must have breast cancer that is advanced or has spread to another part of the body. Study participation could last up to 5 years.
