Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome
研究单位：[1]AbbVie[2]Genentech, Inc.[3]Providence Medical Foundation /ID# 222633,Fullerton,California,United States,92835[4]University of California, Los Angeles /ID# 221760,Los Angeles,California,United States,90095[5]Torrance Memorial Physician Network Cancer Care /ID# 222702,Torrance,California,United States,90505-5004[6]PIH Health Whittier Hospital /ID# 222647,Whittier,California,United States,90602-1006[7]Rocky Mountain Cancer Centers /ID# 223723,Boulder,Colorado,United States,80303[8]Yale University /ID# 222764,New Haven,Connecticut,United States,06510[9]Helen F. Graham Cancer Center & Research Institute /ID# 223731,Newark,Delaware,United States,19713-2055[10]Florida Cancer Specialists - Fort Myers /ID# 221319,Fort Myers,Florida,United States,33916[11]Memorial Healthcare System /ID# 222703,Hollywood,Florida,United States,33021-3513[12]Florida Cancer Specialists - North /ID# 221318,Saint Petersburg,Florida,United States,33705-1449[13]Florida Cancer Specialists - Panhandle /ID# 221315,Tallahassee,Florida,United States,32308-5304[14]Florida Cancer Specialists - East /ID# 221317,West Palm Beach,Florida,United States,33401[15]St. Luke's Mountain State Tumor Institute /ID# 220838,Boise,Idaho,United States,83712-6267[16]Northwestern University Feinberg School of Medicine /ID# 220843,Chicago,Illinois,United States,60611-2927[17]Rush University Medical Center /ID# 221007,Chicago,Illinois,United States,60612[18]Ingalls Memorial Hosp /ID# 220844,Harvey,Illinois,United States,60426[19]Illinois Cancer Care, PC /ID# 220840,Peoria,Illinois,United States,61615[20]Parkview Cancer Institute /ID# 223620,Fort Wayne,Indiana,United States,46845-1739[21]Cancer Center of Kansas /ID# 222648,Wichita,Kansas,United States,67214[22]Hematology/Oncology Clinic /ID# 224257,Baton Rouge,Louisiana,United States,70809[23]Pontchartrain Cancer Center - Covington /ID# 221005,Covington,Louisiana,United States,70433-7512[24]Maryland Oncology Hematology /ID# 223776,Columbia,Maryland,United States,21044-3128[25]Massachusetts General Hospital /ID# 225068,Boston,Massachusetts,United States,02114[26]Beth Israel Deaconess Medical Center /ID# 225069,Boston,Massachusetts,United States,02215-5400[27]Dana-Farber Cancer Institute /ID# 219162,Boston,Massachusetts,United States,02215[28]VA Ann Arbor Healthcare System /ID# 221365,Ann Arbor,Michigan,United States,48105[29]Cancer & Hematology Centers /ID# 220848,Grand Rapids,Michigan,United States,49503[30]Mmcorc /Id# 221321,Saint Louis Park,Minnesota,United States,55416[31]MidAmerica Division, Inc. /ID# 221895,Kansas City,Missouri,United States,64132[32]Comprehensive Cancer Centers of Nevada - Horizon Ridge /ID# 222635,Henderson,Nevada,United States,89052-2648[33]Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 221003,East Brunswick,New Jersey,United States,08816[34]The Valley Hospital /ID# 232337,Paramus,New Jersey,United States,07652[35]New York Oncology Hematology - Albany Cancer Center /ID# 223778,Albany,New York,United States,12206-5013[36]University at Buffalo /ID# 221206,Buffalo,New York,United States,14222[37]Weill Cornell Medical College /ID# 222898,New York,New York,United States,10065[38]Stony Brook University Hospital /ID# 224450,Stony Brook,New York,United States,11794-8183[39]Novant Health Presbyterian Medical Center /ID# 222561,Charlotte,North Carolina,United States,28204[40]Novant Health Forsyth Medical Center /ID# 221004,Winston-Salem,North Carolina,United States,27103[41]Oncology Hematology Care, Inc. /ID# 223724,Cincinnati,Ohio,United States,45236-2725[42]Bend Memorial Clinic /ID# 220999,Bend,Oregon,United States,97701[43]Willamette Valley Cancer Institute and Research Center /ID# 223733,Eugene,Oregon,United States,97401-6043[44]UPMC Hillman Cancer Ctr /ID# 223201,Pittsburgh,Pennsylvania,United States,15232[45]Avera Cancer Institute /ID# 243461,Sioux Falls,South Dakota,United States,57105[46]Tennessee Oncology - Chattanooga / McCallie /ID# 221311,Chattanooga,Tennessee,United States,37404-3230[47]Tennessee Oncology-Nashville Centennial /ID# 220854,Nashville,Tennessee,United States,37203-1632[48]Texas Oncology - Austin Midtown /ID# 223729,Austin,Texas,United States,78705[49]Texas Oncology - Medical City Dallas /ID# 223725,Dallas,Texas,United States,75230[50]Texas Oncology- Baylor Charles A. Sammons Cancer Center /ID# 223727,Dallas,Texas,United States,75246-2003[51]Texas Oncology - Forth Worth /ID# 223777,Fort Worth,Texas,United States,76104-2150[52]MD Anderson Cancer Center at Texas Medical Center /ID# 219163,Houston,Texas,United States,77030-4000[53]Texas Oncology - San Antonio Medical Center /ID# 223728,San Antonio,Texas,United States,78240-5251[54]Baylor Scott & White Medical Center- Temple /ID# 221332,Temple,Texas,United States,76508-0001[55]Texas Oncology - Northeast Texas /ID# 223734,Tyler,Texas,United States,75702[56]Utah Cancer Specialists Salt Lake Clinic /ID# 219160,Salt Lake City,Utah,United States,84106[57]Virginia Cancer Specialists - Gainesville /ID# 223726,Gainesville,Virginia,United States,20155-3257[58]Virginia Commonwealth University Medical Center Main Hospital /ID# 221590,Richmond,Virginia,United States,23219[59]Virginia Cancer Institute at Reynolds Crossing /ID# 221002,Richmond,Virginia,United States,23230[60]VA Puget Sound Health Care System /ID# 221358,Seattle,Washington,United States,98108-1597[61]Blacktown Hospital /ID# 234079,Blacktown,New South Wales,Australia,2148[62]St George Hospital /ID# 221810,Kogarah,New South Wales,Australia,2217[63]Port Macquarie Base Hospital /ID# 234078,Port Macquarie,New South Wales,Australia,2444[64]Gold coast University Hospital /ID# 222606,SouthPort,Queensland,Australia,4215[65]Royal Adelaide Hospital /ID# 221805,Adelaide,South Australia,Australia,5000[66]St Vincent's Hospital Melbourne /ID# 221809,Fitzroy Melbourne,Victoria,Australia,3065[67]Austin Health /ID# 221807,Heidelberg,Victoria,Australia,3084[68]Ordensklinikum Linz GmbH Elisabethinen /ID# 221387,Linz,Oberoesterreich,Austria,4010[69]Klinikum Wels-Grieskirchen GmbH /ID# 221386,Wels,Oberoesterreich,Austria,4600[70]Medizinische Universitaet Wien /ID# 221446,Vienna,Wien,Austria,1090[71]Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 221092,Salzburg,Austria,5020[72]Hanusch Krankenhaus /ID# 221093,Wien,Austria,1140[73]UCL Saint-Luc /ID# 219066,Woluwe-Saint-Lambert,Bruxelles-Capitale,Belgium,1200[74]CHU UCL Namur - site Godinne /ID# 219064,Godinne,Namur,Belgium,5530[75]UZ Gent /ID# 218767,Gent,Oost-Vlaanderen,Belgium,9000[76]Universitair Ziekenhuis Leuven /ID# 218905,Leuven,Vlaams-Brabant,Belgium,3000[77]ZNA Middelheim /ID# 218907,Antwerp,Belgium,2020[78]AZ Sint-Jan Brugge /ID# 218212,Brugge,Belgium,8000[79]Pôle Hospitalier Jolimont /ID# 218921,La Louvière,Belgium,7100[80]Hospital Universitario Walter Cantidio /ID# 223434,Fortaleza,Ceara,Brazil,60430-372[81]Liga Paranaense de Combate ao Câncer /ID# 221341,Curitiba,Parana,Brazil,81520-060[82]Sociedade Beneficente Israelita Hospital Albert Einstein /ID# 221370,São Paulo,Sao Paulo,Brazil,05652-900[83]Hospital Universitário Pedro Ernesto /ID# 223080,Rio de Janeiro,Brazil,20551-030[84]Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo /ID# 221339,Sao Paulo,Brazil,05403-000[85]BC Cancer - Surrey /ID# 219098,Surrey,British Columbia,Canada,V3V 1Z2[86]Ottawa Hospital Research Institute /ID# 219105,Ottawa,Ontario,Canada,K1H 8L6[87]Sunnybrook Health Sciences Ctr /ID# 219103,Toronto,Ontario,Canada,M4N 3M5[88]McGill University Health Center Research Institute /ID# 222519,Montreal,Quebec,Canada,H4A 3J1[89]CIUSSS du Nord-de-l'ile-de-Montréal_Hopital du Sacré-Coeur de Montréal /ID# 218973,Montreal,Quebec,Canada,H4J 1C5[90]CHUQ- Hôpital de l'Enfant-Jesus /ID# 221200,Quebec City,Quebec,Canada,G1J 1Z4[91]Guangdong Provincial People's Hospital /ID# 221442,Guangzhou,Guangdong,China,510080[92]Zhujiang Hospital of Southern Medical University /ID# 222071,Guangzhou,Guangdong,China,510280[93]Nanfang Hospital of Southern Medical University /ID# 224566,Guangzhou,Guangdong,China,510515[94]The Second Hospital of Hebei Medical University /ID# 222919,Shijiazhuang,Hebei,China,050000[95]Henan Provincial People's Hospital /ID# 225790,Zhengzhou,Henan,China,450003[96]Henan Cancer Hospital /ID# 221447,Zhengzhou,Henan,China,450008[97]Zhongda Hospital Southeast University /ID# 221849,Nanjing,Jiangsu,China,210009[98]Jiangsu Province Hospital /ID# 221342,Nanjing,Jiangsu,China,210029[99]The First Affiliated Hospital of Soochow University /ID# 221640,Suzhou,Jiangsu,China,215031[100]The First Affiliated Hospital of Nanchang University /ID# 225983,Nanchang,Jiangxi,China,330006[101]Shaanxi Provincial people's Hospital /ID# 225728,Xi'an,Shaanxi,China,710000[102]Shanghai Sixth People's Hospital /ID# 221546,Shanghai,Shanghai,China,200233[103]West China Hospital, Sichuan University /ID# 221601,Chengdu,Sichuan,China,610041[104]Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 221567,Tianjin,Tianjin,China,300020[105]The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 221494,Hangzhou,Zhejiang,China,310006[106]Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 225982,Hangzhou,Zhejiang,China,310020[107]The Fourth Affiliated Hospital Zhejiang University School of Medicine /ID# 225918,Yiwu,Zhejiang,China,322000[108]Peking University International Hospital /ID# 222987,Beijing,China,102206[109]Lanzhou University Second Hospital /ID# 225980,Lanzhou,China,730030[110]Shengjing Hospital of China Medical University /ID# 222945,Shenyang,China,110022[111]Tianjin Medical University General Hospital /ID# 226810,Tianjin,China,300052[112]Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 221475,Wuhan,China,420022[113]Tongji Hospital Tongji Medical College of HUST /ID# 221474,Wuhan,China,430030[114]Fakultni Nemocnice Brno /ID# 221351,Brno,Czechia,625 00[115]Fakultni nemocnice Hradec Kralove /ID# 221163,Hradec Kralove,Czechia,500 05[116]Fakultni nemocnice Ostrava /ID# 219143,Ostrava,Czechia,708 52[117]Fakultni nemocnice Plzen /ID# 221162,Plzen,Czechia,305 99[118]Ustav hematologie a krevni transfuze /ID# 221350,Praha,Czechia,128 00[119]Vseobecna fakultni nemocnice v Praze /ID# 221229,Praha,Czechia,128 08[120]CHU de Nice - Hôpital Archet 1 /ID# 220992,Nice,Alpes-Maritimes,France,06200[121]CHU Bordeaux - Hopital Haut Leveque /ID# 220989,Pessac,Gironde,France,33604[122]CHRU Lille - Hopital Claude Huriez /ID# 220991,Lille,Hauts-de-France,France,59037[123]CHU de Nantes, Hotel Dieu -HME /ID# 222074,Nantes,Pays-de-la-Loire,France,44000[124]CH Henri Duffaut /ID# 225185,Avignon CEDEX 9,Provence-Alpes-Cote-d Azur,France,84902[125]CHU Grenoble - Hopital Michallon /ID# 220988,La Tronche,France,38700[126]AP-HM - Hopital de la Conception /ID# 224882,Marseille,France,13005[127]AP-HP - Hopital Saint-Louis /ID# 222075,Paris,France,75010[128]Centre Henri Becquerel /ID# 220986,Rouen,France,76038[129]Universitatsklinikum Mannheim /ID# 221172,Mannheim,Baden-Wuerttemberg,Germany,68167[130]Stauferklinikum Schwaebisch Gmuend /ID# 224917,Mutlangen,Baden-Wuerttemberg,Germany,73557[131]Universitaetsklinikum Duesseldorf /ID# 221169,Düsseldorf,Nordrhein-Westfalen,Germany,40225[132]Universitaetsklinikum Koeln /ID# 234219,Köln,Nordrhein-Westfalen,Germany,50937[133]Universitaetsklinikum Leipzig /ID# 221168,Leipzig,Sachsen,Germany,04103[134]Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 221189,Berlin,Germany,12203[135]Medizinische Hochschule Hannover /ID# 221173,Hannover,Germany,30625[136]Klinikum rechts der Isar - Technische Universitaet Muenchen /ID# 221170,Munich,Germany,81675[137]Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont /ID# 221705,Szeged,Csongrad,Hungary,6725[138]Fejer Megyei Szent Gyorgy Korhaz /ID# 222953,Szekesfehervar,Fejer,Hungary,8000[139]Debreceni Egyetem Klinikai Kozpont /ID# 221702,Debrecen,Hajdu-Bihar,Hungary,4032[140]Somogy Megyei Kaposi Mor Oktato Korhaz /ID# 221703,Kaposvár,Somogy,Hungary,7400[141]Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz Josa Andras Okta /ID# 221704,Nyiregyhaza,Szabolcs-Szatmar-Bereg,Hungary,4400[142]The Chaim Sheba Medical Center /ID# 221110,Ramat Gan,Tel-Aviv,Israel,5265601[143]Tel Aviv Sourasky Medical Center /ID# 221896,Tel Aviv-Yafo,Tel-Aviv,Israel,6423906[144]Hadassah Medical Center-Hebrew University /ID# 222006,Jerusalem,Yerushalayim,Israel,91120[145]Rambam Health Care Campus /ID# 221083,Haifa,Israel,3109601[146]Shaare Zedek Medical Center /ID# 233181,Jerusalem,Israel,91031[147]Rabin Medical Center /ID# 221184,Petakh Tikva,Israel,4941492[148]Istituto Clinico Humanitas /ID# 220815,Rozzano,Milano,Italy,20089[149]IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 220810,Bologna,Italy,40138[150]Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli /ID# 220816,Napoli,Italy,80131[151]Grande Ospedale Metropolitano Bianchi Melacrino Morelli /ID# 220818,Reggio Calabria,Italy,89124[152]Azienda Ospedaliero-Universitaria Sant'Andrea /ID# 220819,Rome,Italy,00189[153]Nagoya University Hospital /ID# 221566,Nagoya-shi,Aichi,Japan,4668560[154]University of Fukui Hospital /ID# 221568,Yoshida-gun,Fukui,Japan,910-1193[155]Kyushu University Hospital /ID# 223473,Fukuoka-shi,Fukuoka,Japan,812-8582[156]Fukushima Medical University Hospital /ID# 222015,Fukushima-shi,Fukushima,Japan,960-1295[157]Chugoku Central Hospital /ID# 222955,Fukuyama-shi,Hiroshima,Japan,720-0001[158]Sapporo Hokuyu Hospital /ID# 222133,Sapporo-shi,Hokkaido,Japan,003-0006[159]Aiiku Hospital /ID# 222351,Sapporo-shi,Hokkaido,Japan,064-0804[160]Kobe City Medical Center General Hospital /ID# 221977,Kobe-shi,Hyogo,Japan,650-0047[161]National Hospital Organization Mito Medical Center /ID# 222278,Higashi Ibaraki-gun,Ibaraki,Japan,311-3193[162]Tohoku University Hospital /ID# 221976,Sendai-shi,Miyagi,Japan,9808574[163]Nagasaki University Hospital /ID# 222241,Nagasaki-shi,Nagasaki,Japan,852-8501[164]Okayama Medical Center /ID# 222310,Okayama-shi,Okayama,Japan,701-1192[165]Kindai University Hospital /ID# 222284,Osakasayama-shi,Osaka,Japan,589-8511[166]Saitama Medical Center /ID# 222016,Kawagoe-shi,Saitama,Japan,350-8550[167]NTT Medical Center Tokyo /ID# 222365,Shinagawa-ku,Tokyo,Japan,141-8625[168]Yamagata University Hospital /ID# 221574,Yamagata-shi,Yamagata,Japan,990-9585[169]Seoul National University Bundang Hospital /ID# 221695,Seongnam,Gyeonggido,Korea, Republic of,13620[170]Yonsei University Health System Severance Hospital /ID# 233171,Seoul,Seoul Teugbyeolsi,Korea, Republic of,03722[171]Pusan National University Hospital /ID# 232353,Busan,Korea, Republic of,49241[172]Seoul National University Hospital /ID# 221226,Seoul,Korea, Republic of,03080[173]Asan Medical Center /ID# 221227,Seoul,Korea, Republic of,05505[174]Samsung Medical Center /ID# 221224,Seoul,Korea, Republic of,06351[175]Erasmus Medisch Centrum /ID# 218937,Rotterdam,Zuid-Holland,Netherlands,3015 GD[176]Maxima Medisch Centrum /ID# 223010,Eindhoven,Netherlands,5631 BM[177]Medisch Spectrum Twente /ID# 223012,Enschede,Netherlands,7512 KZ[178]Maastricht Universitair Medisch Centrum /ID# 221630,Maastricht,Netherlands,6229 HX[179]Isala /ID# 223011,Zwolle,Netherlands,8025 AB[180]Szpital Uniwersytecki nr 2 im. Dr. Jana Biziela /ID# 233321,Bydgoszcz,Kujawsko-pomorskie,Poland,85-168[181]Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii im. M. Kopern /ID# 221784,Lodz,Lodzkie,Poland,93-513[182]Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie /ID# 221667,Lublin,Lubelskie,Poland,20-081[183]LUX MED Onkologia - Szpital Szamocka /ID# 222203,Warszawa,Mazowieckie,Poland,01-748[184]Uniwersyteckie Centrum Kliniczne /ID# 222069,Gdansk,Pomorskie,Poland,80-214[185]Pratia Onkologia Katowice /ID# 224728,Katowice,Poland,40-519[186]MTZ Clinical Research Powered by Pratia /ID# 221354,Warszawa,Poland,02-172[187]Pan American Center for Oncology Trials, LLC /ID# 221010,Rio Piedras,Puerto Rico,00935[188]VA Caribbean Healthcare System /ID# 221012,San Juan,Puerto Rico,00921-3201[189]Kaluga Regional Clinical Hospital /ID# 221211,Kaluga,Kaluzhskaya Oblast,Russian Federation,248007[190]Clinic UZI 4D /ID# 221215,Pyatigorsk,Stavropol Skiy Kray,Russian Federation,357502[191]Hospital n.a. V.V. Veresaev /ID# 225435,Moscow,Russian Federation,127644[192]MMCC Kommunarka /ID# 221213,Moscow,Russian Federation,129301[193]Republican hospital named after V.A. Baranov /ID# 221214,Petrozavodsk,Russian Federation,185019[194]Almazov National Medical Research Centre /ID# 221449,Sankt-Peterburg,Russian Federation,197341[195]Hospital Universitario Germans Trias I Pujol /ID# 221274,Badalona,Barcelona,Spain,08916[196]Hospital Universitario Quironsalud Madrid /ID# 221275,Pozuelo de Alarcon,Madrid,Spain,28223[197]Hospital Universitario Vall d'Hebron /ID# 221323,Barcelona,Spain,08035[198]Hospital Universitario Reina Sofia /ID# 221273,Cordoba,Spain,14004[199]Hospital General Universitario Gregorio Maranon /ID# 221271,Madrid,Spain,28007[200]Hospital Universitario 12 de Octubre /ID# 221272,Madrid,Spain,28041[201]Hospital Universitario de Salamanca /ID# 221297,Salamanca,Spain,37711[202]Hospital Universitario Virgen del Rocio /ID# 221276,Sevilla,Spain,41013[203]Hospital Universitario y Politecnico La Fe /ID# 221270,Valencia,Spain,46026[204]Kaohsiung Chang Gung Memorial Hospital /ID# 223573,Kaohsiung,Taiwan,833[205]China Medical University Hospital /ID# 218987,Taichung City,Taiwan,40447[206]National Cheng Kung University Hospital /ID# 218989,Tainan,Taiwan,704[207]Chi-Mei Medical Center /ID# 218991,Tainan,Taiwan,71004[208]Erciyes University Medical Fac /ID# 222090,Melikgazi,Kayseri,Turkey,38030[209]Hacettepe University Faculty of Medicine /ID# 222094,Ankara,Turkey,06100[210]Ankara City Hospital /ID# 222093,Ankara,Turkey,06800[211]Akdeniz Universitesi Tip Fakul /ID# 222095,Antalya,Turkey,07059[212]Ondokuz mayis University Facul /ID# 222091,Samsun,Turkey,55200[213]Acibadem Maslak Hastanesi /ID# 222072,Tuzla,Turkey,34953[214]University Hospitals Bristol NHS Foundation Trust /ID# 222510,Bristol,Bristol, City Of,United Kingdom,BS1 3NU[215]Oxford University Hospitals NHS Foundation Trust /ID# 221231,Oxford,Oxfordshire,United Kingdom,OX3 9DU[216]Cardiff & Vale University Health Board /ID# 221236,Cardiff,Wales,United Kingdom,CF14 4XN[217]NHS Grampian /ID# 222509,Aberdeen,United Kingdom,AB15 6RE[218]University Hospitals Birmingham NHS Foundation Trust /ID# 221233,Birmingham,United Kingdom,B15 2TH[219]University College London Hospitals NHS Foundation Trust /ID# 221240,London,United Kingdom,NW1 2PG[220]The Royal Marsden NHS Foundation Trust /ID# 221232,London,United Kingdom,SW3 6JJ[221]University Hospital Plymouth NHS Trust /ID# 222514,Plymouth,United Kingdom,PL6 5FP[222]University Hospitals Dorset NHS Foundation Trust /ID# 221237,Poole,United Kingdom,BH15 2JB
Myelodysplastic Syndrome (MDS) is a group of disorders that gradually affect the ability of a person's bone marrow (semi-liquid tissue present in many bones like backbones) to produce normal blood cells. Some people with MDS have a risk of the disease progressing to acute myeloid leukemia (AML), and a risk of death from the disease itself. Symptoms of MDS include fatigue, shortness of breath, unusual paleness due to anemia (low red blood cell count), easy or unusual bruising, and red spots just beneath the skin caused by bleeding. The purpose of this study is to see how safe and effective venetoclax and azacitidine (AZA) combination are when compared to AZA and a placebo (contains no medicine), in participants with newly diagnosed higher-risk MDS. Venetoclax is an investigational drug being developed for the treatment of MDS. The study consists of two treatment arms - In one arm, participants will receive venetoclax and AZA. In another arm, participants will receive AZA and placebo. Adult participants with newly diagnosed higher-risk MDS will be enrolled. Around 500 participants will be enrolled in approximately 220 sites worldwide. Participants in one arm will receive oral doses of venetoclax tablet and intravenous (infusion in the vein) or subcutaneous (given under the skin) AZA solution. Participants in another arm will receive oral doses of placebo tablet and intravenous or subcutaneous AZA solution. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the course of the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood and bone marrow tests, checking for side effects, and completing questionnaires.
