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A Study Evaluating Safety and Efficacy of Venetoclax in Combination With Azacitidine Versus Standard of Care After Allogeneic Stem Cell Transplantation (SCT) in Participants With Acute Myeloid Leukemia (AML)

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研究单位: [1]AbbVie [2]Arizona Oncology - Scottsdale - Cancer Transplant Institute Location [3]University of Arizona Cancer Center - Tucson [4]Tongji Hospital Tongji Medical College Huazhong University of Science and Techno

关键词: Acute Myeloid Leukemia (AML) Venetoclax Azacitidine Stem Cell Transplantation (SCT) Best Support Care (BSC) Cancer

研究目的:
This study will have 2 parts: Part 1 (Dose Confirmation), which may include participants who are greater than or equal to 18 years old; Part 2 (Randomization) which may include participants who are greater than or equal to 12 years old. During Part 1, recommended Phase 3 dose of venetoclax in combination with azacitidine will be determined and during Part 2, the efficacy and safety of venetoclax with azacitidine (Part 2 Arm A) will be compared with BSC (Part 2 Arm B).

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