研究单位：[1]Incyte Corporation[2]Mayo Clinic Arizona,Phoenix,Arizona,United States,85054[3]Marin Cancer Care,Greenbrae,California,United States,94904[4]Georgetown University-Lombardi Comprehensive Cancer Center,Washington,District of Columbia,United States,20007[5]Mayo Clinic-Florida,Jacksonville,Florida,United States,32224[6]Mount Sinai Medical Center Comprehensive Cancer Center,Miami Beach,Florida,United States,33140[7]Winship Cancer Institute of Emory University,Atlanta,Georgia,United States,30322[8]University of Chicago Medical Center,Chicago,Illinois,United States,60637-1447[9]Parkview Research Center,Fort Wayne,Indiana,United States,46845[10]University of Iowa Hospital and Clinics,Iowa City,Iowa,United States,52242[11]The University of Kansas Cancer Center,Westwood,Kansas,United States,66205[12]Ochsner Clinic Foundation Ocf Ochsner Cancer Institute Oci,New Orleans,Louisiana,United States,70121[13]Johns Hopkins Oncology Center,Baltimore,Maryland,United States,21287[14]Boston Medical Center,Boston,Massachusetts,United States,02118[15][16Beth Israel Deaconess Medical Center,Boston,Massachusetts,United States,02215[16]Barbara Ann Karmanos Cancer Hospital,Detroit,Michigan,United States,48201[17]Henry Ford Hospital,Detroit,Michigan,United States,48202[18]Karmanos Cancer Institute,Farmington Hills,Michigan,United States,48334[19]Mayo Clinic,Rochester,Minnesota,United States,55905[20]Comprehensive Cancer Centers of Nevada-Twain,Las Vegas,Nevada,United States,89169[21]Summit Medical Group,Florham Park,New Jersey,United States,07932[22]Icahn School of Medicine At Mount Sinai,New York,New York,United States,10029[23]White Plains Hospital,White Plains,New York,United States,10601[24]University Hospitals Cleveland Medical Center,Cleveland,Ohio,United States,44106[25]Cleveland Clinic Foundation,Cleveland,Ohio,United States,44195[26]Providence Portland Med. Ctr,Portland,Oregon,United States,97213[27]Oregon Health & Science University,Portland,Oregon,United States,97239[28]Fox Chase Cancer Center,Philadelphia,Pennsylvania,United States,19111[29]Greenville Hospital System University Medical Center Institute For Translational Oncology Research,Greenville,South Carolina,United States,29605[30]Baylor Scott and White Research Institute,Dallas,Texas,United States,75246[31]Houston Methodist Research Institute,Houston,Texas,United States,77030[32]Riverside Regional Medical Center,Newport News,Virginia,United States,23601[33]Virginia Commonwealth University,Richmond,Virginia,United States,23229[34]Virginia Mason Medical Center,Seattle,Washington,United States,98101[35]West Virginia University Cancer Institute,Morgantown,West Virginia,United States,26506[36]Aurora Research Institute,Wauwatosa,Wisconsin,United States,53226[37]Landeskrankenhaus Universitatsklinikum Graz,Graz,Austria,08036[38]Innsbruck University Hospital,Innsbruck,Austria,A-6020[39]Ordensklinikum Krankenhaus Der Barmherzigen Schwestern Linz,Linz,Austria,04010[40]Salzburger Universitatsklinikum,Salzburg,Austria,05020[41]Landeskrankenhaus Steyr,Steyr,Austria,04400[42]Allgemeines Krankenhaus Der Stadt Wien,Vienna,Austria,01090[43]Ulb Hospital Erasme,Bruxelles,Belgium,01070[44]Universitair Ziekenhuis Brussel,Bruxelles,Belgium,01090[45]Universitair Ziekenhuis Gent,Gent,Belgium,09000[46]Hospital de Jolimont,Haine-st-paul,Belgium,07100[47]Az Groeninge Campus Kennedylaan,Kortrijk,Belgium,08500[48]Universitaire Ziekenhuis Leuven - Gasthuisberg,Leuven,Belgium,03000[49]Chu Ucl Namur University Hospital Mont-Godinne,Yvoir,Belgium,05530[50]Tom Baker Cancer Centre,Calgary,Alberta,Canada,T2N 4N2[51]Cancercare Manitoba,Winnipeg,Manitoba,Canada,R3E 0V9[52]Nova Scotia Health Authority/Qeii Health Sciences Centre,Halifax,Nova Scotia,Canada,B3H 4K4[53]Princess Margaret Cancer Center,Toronto,Ontario,Canada,MG5 2M9[54]McGill University Health Centre Research Institute,Montreal,Quebec,Canada,H4A 3J1[55]Peking Union Medical College Hospital,Beijing,China,100032[56]West China Hospital Sichuan University,Chengdu,China,610041[57]Fujian Cancer Hospital,Fuzhou,China,350005[58]Sun Yat-Sen Memorial Hospital Sun Yat-Sen University,Guangdong,China,510000[59]Sun Yat-Sen Memorial Hospital Sun Yat-Sen University,Guangzhou,China,510000[60]Shulan Hangzhou Hospital Co Ltd,Hangzhou,China,310000[61]The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou,China,310009[62]Heilongjiang Province Cancer Hospital,Harbin,China,150081[63]University of Science and Technology of China-First Affiliated Hospital (Anhui Provincial Hospital),Hefei,China,230001[64]Kunming 1St People'S Hospital,Kunming,China,650032[65]Jiangsu Province Hospital,Nanjing,China,210029[66]The Affiliated Hospital of Qingdao University,Shandong,China,266071[67]Zhongshan Hospital Fudan University,Shanghai,China,200032[68]Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China,200092[69]Xinhua Hospital,Shanghai,China,200092[70]Sichuan Cancer Hospital,Sichuan,China,610041[71]Tianjin Medical University Cancer Institute Hospital,Tianjin,China,300060[72]Tongji Hospital Huazhong University of Science and Technology,Wuhan,China,430030[73]Hubei Cancer Hospital,Wuhan,China,430079[74]Northern Jiangsu Peoples Hospital,Yangzhou,China,225001[75]Herlev Og Gentofte Hospital,Herlev,Denmark,02730[76]Docrates Cancer Center,Helsinki,Finland,00180[77]Helsinki University Central Hospital,Helsinki,Finland,00290[78]Tampere University Hospital,Tampere,Finland,33521[79]Institut Sainte Catherine,Avignon Cedex 9,France,84918[80]Chu Besancon Hospital Jean Minjoz,Besançon,France,25030[81]Institut Bergonie,Bordeaux Cedex,France,33076[82]Hopital Beaujon,Clichy,France,92110[83]Chu de Limoges - Hospital Dupuytren,Limoges Cedex,France,87042[84]Hopital Prive Jean Mermoz,Lyon Cedex 08,France,69373[85]Chu Hopital de La Timone,Marseille Cedex 5,France,13385[86]Centre Hospitalier Universitaire de Nantes,Nantes,France,44000[87]Centre Antoine Laccassagne,Nice Cedex 02,France,06189[88]Hospital Universitaire Pitie-Salpetriere,Paris Cedex 13,France,75013[89]Hopital Europeen Georges Pompidou (Hegp),Paris Cedex 15,France,75015[90]Centre Hospitalier Universitaire de Bordeaux - Hospital Haut-Leveque,Pessac Cedex,France,336600[91]Hospital de La Miletrie,Poitiers Cedex,France,86021[92]Hopital Charles Nicolle Chu Rouen Hospital de Bois-Guillaume,Rouen Cedex,France,76031[93]University Hospital of Saint Etienne,Saint Etienne,France,42055[94]Centre de Lutte Contre Le Cancer - Institut de Cancerologie de L'Ouest - Rene Gauducheau,Saint Herblain,France,44800[95]Chu Toulouse Hopital Rangueil,Toulouse Cedex 9,France,31059[96]Chu Vandoeuvre-Les-Nancy Hopital Brabois,Vandoeuvre Les Nancy,France,54511[97]Institut Gustave Roussy,Villejuif Cedex,France,94805[98]University Medical Center Rwth Aachen,Aachen,Germany,52074[99]Charite - Campus Virchow-Klinikum,Berlin,Germany,13353[100]Charite Universitaetsmedizin Berlin - Campus Charite Mitte,Berlin,Germany,13353[101]Universitatsklinikum Bonn Aoer,Bonn,Germany,53127[102]Klinikum Bremen-Nord,Bremen,Germany,28755[103]University Clinic Carl Gustav Carus Technical University Dresden,Dresden,Germany,01307[104]Klinikum Der Johann Wolfgang Goethe University,Frankfurt,Germany,60590[105]University Medical Center Freiburg,Freiburg,Germany,79106[106]Universitatsklinikum Hamburg Eppendorf,Hamburg,Germany,20246[107]Asklepios Klinik Altona,Hamburg,Germany,22763[108]Hannover Medical School,Hannover,Germany,30625[109]Universitaetsklinikum Des Saarlandes,Homburg / Saar,Germany,66421[110]Universitatsklinikum Koln,Koln,Germany,50937[111]Universitatsklinikum Leipzig Aor,Leipzig,Germany,04103[112]Klinikum Ludwigsburg,Ludwigsburg,Germany,71640[113]Otto-Von-Guericke-Universitat Magdeburg,Magdeburg,Germany,39120[114]Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii,Mainz,Germany,55131[115]University Hospital Grosshadern Munich,Munich,Germany,81377[116]Klinikum Nuernberg,Nuernberg,Germany,90419[117]Universitaetsklinikum in Tubingen,Tubingen,Germany,72076[118]University Hospital Tuebingen,Tubingen,Germany,72076[119]Universitatkinikums Ulm,ULM,Germany,89081[120]St. Vincent'S University Hospital,Dublin 4,Ireland,D04 Y8V0[121]Soroka University Medical Center,Beer-sheva,Israel,84001[122]Rambam Health Care Campus,Haifa,Israel,3109601[123]Hadassah University Hospital,Jerusalem,Israel,9112001[124]Rabin Medical Center - Beilinson Hospital,Petach Tikva,Israel,4941492[125]Tel Aviv Sourasky Medical Center,Tel Aviv,Israel,64239[126]Azienda Ospedaliero Universitaria Ospedali Riuniti,Ancona,Italy,60126[127]Istituto Tumori Giovanni Paolo Ii Irccs Ospedale Oncologico Bari,Bari,Italy,70124[128]Ospedale Papa Giovanni Xxiii,Bergamo,Italy,24127[129]Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi,Bologna,Italy,40138[130]Fondazione Del Piemonte Per L'Oncologia Ircc Candiolo,Candiolo,Italy,10060[131]Presidio Ospedaliero Garibaldi Nesima,Catania,Italy,95100[132]Ospedale Degli Infermi - Faenza,Faenza,Italy,48018[133]Irccs Azienda Ospedaliera Universitaria San Martino,Genova,Italy,16132[134]Comitato Etico Fondazione Irccs Istituto Nazionale Dei Tumori Milano,Milano,Italy,20133[135]Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) Ospedale San Raffaele,Milan,Italy,20132[136]European Institute of Oncology,Milan,Italy,20141[137]Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda,Milan,Italy,20162[138]A.O.U. Di Modena - Policlinico,Modena,Italy,41124[139]Istituto Nazionale Tumori Irccs Fondazione Pascale,Napoli,Italy,80131[140]Universita Degli Studi Della Campania Luigi Vanvitelli U.O.C. Oncologia Medica,Napoli,Italy,80138[141]Azienda Ospedaliera Universitaria San Luigi Gonzaga Orbassano,Orbassano,Italy,10043[142]Iov - Istituto Oncologico Veneto Irccs,Padova,Italy,35128[143]Presidio Ospedaliero Pescara,Pescara,Italy,65124[144]Azienda Ospedaliera Universitaria Pisana,Pisa,Italy,56126[145]Fondazione Policlinico Universitario Agostino Gemelli Irccs,Roma,Italy,00137[146]Istituto Nazionale Tumori Regina Elena Irccs,Roma,Italy,00144[147]Universita Campus Bio Medico Di Roma,Rome,Italy,00128[148]Azienda Ospedaliera San Camillo Forlanini,Rome,Italy,00152[149]Irccs Istituto Clinico Humanitas,Rozzano,Italy,20089[150]Azienda Ospedaliera Universitaria Senese Policlinico Santa Maria Alle Scotte,Siena,Italy,53100[151]Centro Ricerche Cliniche Di Verona (Crc),Verona,Italy,37134[152]San Bartolo Hospital,Vicenza,Italy,36100[153]University of Tokyo Hospital,Bunkyo,Japan,113-8655[154]Chiba University Hospital,Chiba,Japan,260-8677[155]Chiba Cancer Center,Chiba,Japan,260-8717[156]National Hospital Organization Kyushu Cancer Center,Fukuoka-shi,Japan,812-8582[157]National Hospital Organization Kyushu Cancer Center,Fukuoka,Japan,811-1395[158]Hiroshima University Hospital,Hiroshima-shi,Japan,734-8551[159]Hokkaido University Hospital,Hokkaido,Japan,060-8648[160]Hyogo College of Medicine Hospital,Hyogo,Japan,663-8501[161]Kanazawa University Hospital,Ishikawa,Japan,920-8641[162]Teikyo University Hospital,Itabashi-ku,Japan,173-8606[163]Kobe University Hospital,Kobe-shi,Japan,650-0017[164]Cancer Institute Hospital of Jfcr,Koto-ku,Japan,135-8550[165]Kyoto University Hospital,Kyoto-shi,Japan,606-8507[166]Nho Shikoku Cancer Center,Matsuyama-shi,Japan,791-0280[167]Kyorin University Hospital,Mitaka-shi,Japan,181-8611[168]Aichi Cancer Center Hospital,Nagoya-shi,Japan,464-8681[169]Niigata Cancer Center Hospital,Niigata,Japan,951-8566[170]Osaka International Cancer Institute,Osaka-shi,Japan,541-8567[171]Kindai University Hospital,Osakasayama City,Japan,589-8511[172]Saitama Cancer Center,Saitama,Japan,362-0806[173]Tohoku University Hospital,Sendai-shi,Japan,980-8574[174]Jichi Medical University Hospital,Shimotsuke-shi,Japan,329-0498[175]Keio University Hospital,Shinjuku-ku,Japan,160-8582[176]Shizuoka Cancer Center,Shizuoka,Japan,411-8777[177]Osaka University Hospital,Suita-shi,Japan,565-0871[178]Toyama University Hospital,Toyama,Japan,930-0194[179]Yamaguchi University Hospital,UBE,Japan,755-8505[180]Wakayama Medical University Hospital,Wakayama,Japan,641-8509[181]Yokohama City University Medical Center,Yokohama-shi,Japan,232-0024[182]Kanagawa Cancer Center,Yokohama-shi,Japan,241-8515[183]Oita University Hospital,Yufu-shi,Japan,879-5593[184]Amsterdam University Medical Centre,Amsterdam,Netherlands,1100 DD[185]Maastricht Umc+,Maastricht,Netherlands,6202 AZ[186]Erasmus Medical Center,Rotterdam,Netherlands,3015 CE[187]Umc Utrecht,Utrecht,Netherlands,3584 CX[188]Oslo University Hospital,Oslo,Norway,00450[189]Hospital de La Santa Creu I Sant Pau,Barcelona,Spain,08026[190]Hospital General Universitario Vall D Hebron,Barcelona,Spain,08035[191]Hospital Clinic Barcelona Main,Barcelona,Spain,08036[192]Hospital Clinic Barcelona Main,Barcelona,Spain,08036[193]Hospital Universitario Reina Sofia,Cordoba,Spain,14004[194]Hospital Universitario Reina Sofia,Córdoba,Spain,14004[195]Hospital Materno Teresa Herrera,La Coruña,Spain,15006[196]Hospital General Universitario Gregorio Maranon,Madrid,Spain,28007[197]Hospital Universitario Ramon Y Cajal,Madrid,Spain,28034[198]Hospital Universitario Hm Sanchinarro,Madrid,Spain,28050[199]Hospital Regional Universitario de Malaga,Málaga,Spain,29010[200]Clinica Universidad de Navarra (Cun),Pamplona,Spain,31008[201]Hospital Universitari Parc Tauli,Sabadell,Spain,08208[202]HOSPITAL UNiVERSITARIO DONOSTIA,San Sebastian,Spain,20014[203]Hospital Universitario Marques de Valdecilla,Santander,Spain,39008[204]Hospital General Universitario de Valencia,Valencia,Spain,46014[205]Sahlgrenska University Hospital,Göteborg,Sweden,413 46[206]Karolinska Institute Universitetssjukhuset Solna,Solna,Sweden,171 64[207]Inselspital - Universitaetsspital Bern,Bern,Switzerland,03010[208]Universitatsspital Zurich,Zuerich,Switzerland,08091[209]Aberdeen Royal Infirmary,Aberdeen,United Kingdom,AB25 2ZN[210]Addenbrooke'S Hospital,Cambridge,United Kingdom,CB2 0QQ[211]Velindre Cancer Centre,Cardiff,United Kingdom,CF14 2TL[212]University Hospital Coventry and Warwickshire,Coventry,United Kingdom,CV2 2DX[213]The Royal Marsden Nhs Foundation Trust - Chelsea,London,United Kingdom,SW3 6JJ[214]Imperial College Healthcare Nhs Trust - Hammersmith Hospital,London,United Kingdom,W12 0HS[215]University College London Hospitals (Uclh),London,United Kingdom,WC1E 6BT[216]Kent Oncology Centre - Maidstone Hospital,Maidstone,United Kingdom,ME16 9QQ[217]The Christie Nhs Foundation Trust,Manchester,United Kingdom,M20 4BV[218]The Royal Marsden Nhs Foundation Trust - Sutton,Sutton,United Kingdom,SM2 5PT
The purpose of this study is to evaluate the efficacy and safety of pemigatinib versus gemcitabine plus cisplatin chemotherapy in first-line treatment of participants with unresectable or metastatic cholangiocarcinoma with FGFR2 rearrangement.
