单位：[1]Chinese Acad Med Sci & Peking Union Med Coll, Dept Rheumatol & Clin Immunol, Beijing 100730, Peoples R China[2]Minist Sci & Technol, Natl Clin Res Ctr Dermatol & Immunol Dis NCRC DID, Beijing 100730, Peoples R China[3]Peking Union Med Coll Hosp PUMCH, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China[4]Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing 100730, Peoples R China[5]Zhengzhou Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Zhengzhou, Peoples R China[6]Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Stomatol, Beijing, Peoples R China[7]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Rheumatol, Wuhan, Peoples R China内科学系风湿免疫内科华中科技大学同济医学院附属同济医院[8]Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Pathol, Beijing, Peoples R China
To identify the phenotypic features and clinical significance of peripheral T helper (Tph) like cells in IgG4-RD, 54 untreated IgG4-RD patients and 57 healthy controls (HCs) were enrolled. Flow cytometry analysis, ELISA and correlation analysis were performed. Results indicated that percentages of CD4 + CXCR5-PD-1+ Tph like cells in the peripheral blood of IgG4-RD patients were significantly higher than those of HCs (2.27% +/- 1.99% vs 1.12% +/- 0.98%, P < 0.001). Expression of CD38, CD25, and TIGIT was higher, whereas that of CCR7, CD127 was lower in the Tph like cells from the IgG4-RD patients than in those from the HCs. The IgG4-RD patients with affected internal organs had higher circulating Tph like cell levels than those without (2.69% +/- 1.99% vs 1.23% +/- 0.93%, respectively, P = 0.003). In addition, Tph like cells correlated with serum IgG and IgG4 and peripheral plasmablast levels which could be a promising biomarker for disease activity monitoring.
基金：
National Natural Science Foundation of China [81771757, 82071839]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [NWB20203346]; Capital's Funds for Health Improvement and Research [2020-2-4017]; Beijing Municipal Science & Technology Com-mission [Z201100005520023]
第一作者单位：[1]Chinese Acad Med Sci & Peking Union Med Coll, Dept Rheumatol & Clin Immunol, Beijing 100730, Peoples R China[2]Minist Sci & Technol, Natl Clin Res Ctr Dermatol & Immunol Dis NCRC DID, Beijing 100730, Peoples R China[3]Peking Union Med Coll Hosp PUMCH, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China[4]Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing 100730, Peoples R China[5]Zhengzhou Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Zhengzhou, Peoples R China
通讯作者：
通讯机构：[1]Chinese Acad Med Sci & Peking Union Med Coll, Dept Rheumatol & Clin Immunol, Beijing 100730, Peoples R China[2]Minist Sci & Technol, Natl Clin Res Ctr Dermatol & Immunol Dis NCRC DID, Beijing 100730, Peoples R China[3]Peking Union Med Coll Hosp PUMCH, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China[4]Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing 100730, Peoples R China[*1]Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, 1 Shuai Fu Yuan, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Panpan,Wang Mu,Chen Yu,et al.Expanded CD4+CXCR5-PD-1+peripheral T helper like cells and clinical significance in IgG4-related disease[J].CLINICAL IMMUNOLOGY.2022,237:doi:10.1016/j.clim.2022.108975.
APA：
Zhang, Panpan,Wang, Mu,Chen, Yu,Li, Jieqiong,Liu, Zheng...&Zhang, Wen.(2022).Expanded CD4+CXCR5-PD-1+peripheral T helper like cells and clinical significance in IgG4-related disease.CLINICAL IMMUNOLOGY,237,
MLA：
Zhang, Panpan,et al."Expanded CD4+CXCR5-PD-1+peripheral T helper like cells and clinical significance in IgG4-related disease".CLINICAL IMMUNOLOGY 237.(2022)
