5,7-Dihydroxy-2-(1,2-isopropyldioxy-4-oxo-cyclohex-5-enyl)-chromen-4-one (DICO) is a novel non-aromatic B-ring flavonoid, isolated mainly from Macrothelypteris viridifrons and has anti-tumour properties. In this study, we investigated the cytotoxicity and underlying biochemical pathways leading to cell death, in response to DICO treatment of a human colon cancer cell line HT-29. Our results indicated that DICO induced apoptosis by elevating the generation of reactive oxygen species, which could be quenched by the antioxidants N-acetyl cysteine. In addition, activation of signal transducer and activator of transcription 3 and suppression of nuclear factor kappa B played a crucial role in DICO-induced apoptosis. Overall, our results provide mechanistic insights into the apoptotic action of a potential anti-tumour drug, DICO.
基金：
National Nature Science Foundation of China [81803841]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wei An-Hua,Zeng Lu,Ruan Jin-Lan,et al.Apoptosis induced by DICO, a novel non-aromatic B-ring flavonoid via a ROS-dependent mechanism in human colon cancer cells[J].NATURAL PRODUCT RESEARCH.2022,36(23):6050-6055.doi:10.1080/14786419.2022.2042283.
APA：
Wei, An-Hua,Zeng, Lu,Ruan, Jin-Lan&Zhou, Dao-Nian.(2022).Apoptosis induced by DICO, a novel non-aromatic B-ring flavonoid via a ROS-dependent mechanism in human colon cancer cells.NATURAL PRODUCT RESEARCH,36,(23)
MLA：
Wei, An-Hua,et al."Apoptosis induced by DICO, a novel non-aromatic B-ring flavonoid via a ROS-dependent mechanism in human colon cancer cells".NATURAL PRODUCT RESEARCH 36..23(2022):6050-6055
