Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality and morbidity. It induces cell death that is responsible for neurological deficits postinjury. There are no therapies that effectively mitigate cell death to treat ICH. This review aims to summarize our knowledge of ICH-induced cell death with a focus on apoptosis and necrosis. We also discuss the involvement of ICH in recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos. We summarize treatment strategies to mitigate brain injury based on particular cell death pathways after ICH.
基金:
National Natural Science Foundation of China [82071331, 81870942, 81520108011]; National Key Research and Development Program of China [2018YFC1312200]; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China; Canadian Institutes of Health Sciences
Zhang Yan,Khan Suliman,Liu Yang,et al.Modes of Brain Cell Death Following Intracerebral Hemorrhage[J].FRONTIERS IN CELLULAR NEUROSCIENCE.2022,16:doi:10.3389/fncel.2022.799753.
APA:
Zhang, Yan,Khan, Suliman,Liu, Yang,Zhang, Ruiyi,Li, Hongmin...&Yong, V. Wee.(2022).Modes of Brain Cell Death Following Intracerebral Hemorrhage.FRONTIERS IN CELLULAR NEUROSCIENCE,16,
MLA:
Zhang, Yan,et al."Modes of Brain Cell Death Following Intracerebral Hemorrhage".FRONTIERS IN CELLULAR NEUROSCIENCE 16.(2022)