Owing to lacking protective effect of estrogen, OVX mice have higher risk of non-alcoholic fatty liver disease compared with normal female mice, when fed with high fat diet. Our study was to explore how estrogen protect against nonalcoholic steatohepatitis in female mice. We found that, lacking estrogen, M1 macrphages was activated and promoted steatohepatitis in obese OVX mice. And, ERa was responsible for estrogen to inhibit M1 macrphages activation and steatohepatitis. ERa knockdown aggravated M1 macrophages infiltration by transcriptionally upregulated its CCR2 expression. CCR2 antagonist effectively improved nonalcoholic steatohepatitis, ER stress and insulin resistance in ERa knockdown obese female mice. These results demonstrated ERa mediated M1 macrophages activation played a key role in nonalcoholic steatohepatitis. (c) 2022 Elsevier Inc. All rights reserved.
基金：
National Natural Science Foundation of China [82071722, 81701417]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nucl Med, 1277 JieFang Ave, Wuhan 430022, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Shu Zhiping,Zhang Guopeng,Zhu Xiaohua,et al.Estrogen receptor α mediated M1/M2 macrophages polarization plays a critical role in NASH of female mice[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2022,596:63-70.doi:10.1016/j.bbrc.2022.01.085.
APA：
Shu, Zhiping,Zhang, Guopeng,Zhu, Xiaohua&Xiong, Wenqian.(2022).Estrogen receptor α mediated M1/M2 macrophages polarization plays a critical role in NASH of female mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,596,
MLA：
Shu, Zhiping,et al."Estrogen receptor α mediated M1/M2 macrophages polarization plays a critical role in NASH of female mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 596.(2022):63-70
