高级检索
当前位置: 首页 > 详情页

Risk Assessment of Pulmonary Metastasis for Cervical Cancer Patients by Ensemble Learning Models: A Large Population Based Real-World Study

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

单位: [1]Hubei Minzu Univ, Affiliated Enshi Clin Med Sch, Dept Anesthesiol, Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Enshi 445000, Hubei, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Natl Clin Res Ctr Obstet & Gynecol Dis, Wuhan 430030, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Key Lab Canc Invas & Metastasis,Minist Educ, Wuhan 430030, Peoples R China [4]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan 430030, Peoples R China [5]Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Dept Oncol, Wuhan, Peoples R China [6]Hubei Minzu Univ, Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Dept Pulm & Crit Care Med, Affiliated Enshi Clin Med Sch, Enshi 445000, Hubei, Peoples R China [7]Hubei Minzu Univ, Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Dept Oncol, Affiliated Enshi Clin Med Sch, Enshi 445000, Hubei, Peoples R China
出处:
ISSN:

关键词: cervical cancer pulmonary metastasis machine learning predictive model prognosis SEER database

摘要:
Objective: Pulmonary metastasis (PM) is an independent risk factor affecting the prognosis of cervical patients, but it still lacks a prediction. This study aimed to develop machine learning-based predictive models for PM. Methods: A total of 22,766 patients diagnosed with or without PM from the Surveillance, Epidemiology, and End Results (SEER) database were enrolled in this study. The cohort was randomly split into a train set (70%) and a validation set (30%). In addition, 884 Chinese patients from two tertiary medical centers were included as an external validation set. Duplicated and useless candidate variables were excluded, and sixteen variables were included for the machine learning algorithm. We developed five predictive models, including the generalized linear model (GLM), random forest model (RFM), naive Bayesian model (NBM), artificial neural networks model (ANNM), and decision tree model (DTM). The predictive performance of these models was evaluated by the receiver operating characteristic (ROC) curve and calibration curve. The Cox proportional hazard model (CPHM) and competing risk model (CRM) were also included for survival outcome prediction. Results: Of the patients included in the analysis, 2456 (4.38%) patients were diagnosed with PM. Age, organ-site metastasis (liver, bone, brain), distant lymph metastasis, tumor size, and pathology were the important predictors of PM. The RFM with 9 variables introduced was identified as the best predictive model for PM (AUC = 0.972, 95% CI: 0.958-0.986). The C-index for the CPHM and CRM was 0.626 (95% CI: 0.604-0.648) and 0.611 (95% CI: 0.586-0.636), respectively. Conclusion: The prediction algorithm derived by machine-learning-based methods shows a robust ability to predict PM. This result suggests that machine learning techniques have the potential to improve the development and validation of predictive modeling in cervical patients with PM.

基金:
语种:
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2020]版:
大类 | 4 区 医学
小类 | 3 区 医学:内科
最新[2025]版:
大类 | 4 区 医学
小类 | 3 区 医学:内科
JCR分区:
出版当年[2019]版:
Q2 MEDICINE, GENERAL & INTERNAL
最新[2024]版:
Q2 MEDICINE, GENERAL & INTERNAL

影响因子: 最新[2024版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者:
第一作者单位: [1]Hubei Minzu Univ, Affiliated Enshi Clin Med Sch, Dept Anesthesiol, Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Enshi 445000, Hubei, Peoples R China
通讯作者:
通讯机构: [1]Hubei Minzu Univ, Affiliated Enshi Clin Med Sch, Dept Anesthesiol, Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Enshi 445000, Hubei, Peoples R China [6]Hubei Minzu Univ, Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Dept Pulm & Crit Care Med, Affiliated Enshi Clin Med Sch, Enshi 445000, Hubei, Peoples R China [7]Hubei Minzu Univ, Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Dept Oncol, Affiliated Enshi Clin Med Sch, Enshi 445000, Hubei, Peoples R China
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:622 今日访问量:0 总访问量:452 更新日期:2025-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有:重庆聚合科技有限公司 渝ICP备12007440号-3 地址:重庆市两江新区泰山大道西段8号坤恩国际商务中心16层(401121)