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COVID-ONE-hi: The One-stop Database for COVID-19 Specific Humoral Immunity and Clinical Parameters.

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：重点期刊

作者：
zhaowei xu[1,2] * ; yang li[1] * ; qing lei[3] * ; likun huang[4] * ; dan-yun lai[1] * ; shu-juan guo[1] * ; he-wei jiang[1] ; hongyan hou[5] ; yun-xiao zheng[1] ; xue-ning wang[1] ; jiaoxiang wu[6] ; ming-liang ma[1] ; bo zhang[5] ; hong chen[1] ; caizheng yu[7] ; jun-biao xue[1] ; hainan zhang[1] ; huan qi[1] ; siqi yu[2] ; mingxi lin[2] ; yandi zhang[3] ; xiaosong lin[3] ; zongjie yao[3] ; huiming sheng[6] ; ziyong sun[3] ; feng wang[5] ; xionglin fan[3] ; sheng-ce tao[1] ;
单位： [1]Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China [2]Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China [3]Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China [4]Fujian Key Laboratory of Crop Breeding by Design, Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350028, China [5]Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China [6]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China [7]Department of Public Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China
出处：
DOI： 10.1016/j.gpb.2021.09.006
ISSN：

关键词： SARS-CoV-2 Protein microarray Humoral immunity One-stop tool Shiny

摘要：
Coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2, varies with regard to symptoms and mortality rates among populations. Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19. However, differences in immune responses and clinical features among COVID-19 patients remain largely unknown. Here, we report a database for COVID-19 specific IgG/IgM immune responses and clinical parameters (COVID-ONE-hi). COVID-ONE-hi is based on the data that contain the IgG/IgM responses to 21 of 28 known SARS-CoV-2 proteins and 197 spike protein peptides against 2,360 serum samples collected from 783 COVID-19 patients. In addition, 96 clinical parameters for the 2,360 serum samples and information for the 783 patients are integrated into the database. Furthermore, COVID-ONE-hi provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups. A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters. After the "START" button is clicked, one can readily obtain a comprehensive analysis report for further interpretation. COVID-ONE-hi is freely available at www.COVID-ONE.cn.Copyright © 2021. Published by Elsevier B.V.

基金：
National Key Research and Development Program of China Grant (Grant No. 2016YFA0500600), National Natural Science Foundation of China (Grant Nos. 31970130, 31600672, 31900112, 21907065, and 32000027).
语种：
外文
被引次数：
WOS：
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中科院(CAS)分区：
出版当年[2020]版：
大类 | 1 区 生物
小类 | 1 区 遗传学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 遗传学
JCR分区：
出版当年[2019]版：
Q1 GENETICS & HEREDITY
最新[2023]版：
Q1 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者单位： [1]Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China [2]Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
zhaowei xu,yang li,qing lei,et al.COVID-ONE-hi: The One-stop Database for COVID-19 Specific Humoral Immunity and Clinical Parameters.[J].GENOMICS PROTEOMICS & BIOINFORMATICS.2021,19(5):669-678.doi:10.1016/j.gpb.2021.09.006.
APA：
zhaowei xu,yang li,qing lei,likun huang,dan-yun lai...&sheng-ce tao.(2021).COVID-ONE-hi: The One-stop Database for COVID-19 Specific Humoral Immunity and Clinical Parameters..GENOMICS PROTEOMICS & BIOINFORMATICS,19,(5)
MLA：
zhaowei xu,et al."COVID-ONE-hi: The One-stop Database for COVID-19 Specific Humoral Immunity and Clinical Parameters.".GENOMICS PROTEOMICS & BIOINFORMATICS 19..5(2021):669-678

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