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Signaling networks in B cell development and related therapeutic strategies

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathogen Biol, Wuhan, Peoples R China [2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept & Inst Urol,Wuhan,Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan Childrens Hosp, Wuhan, Peoples R China [4]Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden [5]NIAID, Rocky Mt Labs, Intracellular Parasites Lab, NIH, Hamilton, MT 59840 USA [6]Univ Hong Kong, LKS Fac Med, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China [7]Lausanne Univ Hosp, Div Immunol & Allergy, Lausanne, Switzerland [8]Univ Lausanne, Lausanne, Switzerland [9]Yangtze Univ, Sch Med, Dept Immunol, Jingzhou, Peoples R China [10]Yangtze Univ, Sch Med, Clin Mol Immunol Ctr, Jingzhou, Peoples R China [11]Zunyi Med Univ, Affiliated Hosp, Dept Pediat 2, Zunyi, Guizhou, Peoples R China

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关键词： B cell development BAFFR BCR IL-7R pre-BCR signal therapeutic strategy

摘要：

B cells are essential for Ab production during humoral immune responses. From decades of B cell research, there is now a detailed understanding of B cell subsets, development, functions, and most importantly, signaling pathways. The complicated pathways in B cells and their interactions with each other are stage-dependent, varying with surface marker expression during B cell development. With the increasing understanding of B cell development and signaling pathways, the mechanisms underlying B cell related diseases are being unraveled as well, making it possible to provide more precise and effective treatments. In this review, we describe several essential and recently discovered signaling pathways in B cell development and take a look at newly developed therapeutic strategies targeted at B cell signaling.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区细胞生物学 3 区血液学 3 区免疫学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区细胞生物学 4 区血液学 4 区免疫学

JCR分区：

出版当年[2020]版：

Q2 CELL BIOLOGY Q2 HEMATOLOGY Q2 IMMUNOLOGY

最新[2024]版：

Q2 HEMATOLOGY Q2 IMMUNOLOGY Q3 CELL BIOLOGY

影响因子： 3.1 最新[2024版] 5.1 最新五年平均 4.962 出版当年[2020版] 5.275 出版当年五年平均 3.757 出版前一年[2019版] 6.011 出版后一年[2021版]

第一作者：

第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathogen Biol, Wuhan, Peoples R China

通讯作者：

通讯机构： [9]Yangtze Univ, Sch Med, Dept Immunol, Jingzhou, Peoples R China [10]Yangtze Univ, Sch Med, Clin Mol Immunol Ctr, Jingzhou, Peoples R China

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