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Epoxyeicosatrienoic Acids Prevent Cardiomyocytes against Sepsis by A2AR-induced Activation of PI3K and PPARγ.

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收录情况： ◇ SCIE

作者：
yang lei[1] * ; chen chen[2] ; lv bingya[1] ; gao yi[1] ; li guangping[1,*1] ;
单位： [1]Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, the Second Hospital of Tianjin Medical University, Tianjin, People’s Republic of China [2]Departments of Internal Medicine and Gene Therapy Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,People’s Republic of China
出处：
DOI： 10.1016/j.prostaglins.2021.106595
ISSN：

关键词： Sepsis Myocardial dysfunction Inflammation EETs A2AR

摘要：
Although epoxyeicosatrienoic acids (EETs) have multiple protective effects against different diseases, whether they can improve the pathogenesis of lipopolysaccharide (LPS)-induced septic cardiac dysfunction remains unknown. We investigated the effects of EETs on the LPS-induced inflammatory response in myocardial dysfunction mice and H9c2 cardiac myocytes. Cardiac-specific CYP2J2 transgenic mice (Tr) showed improved cardiac function and reduced inflammation response after administration with LPS, while the protective effects were not observed in A2A adenosine receptor (A2AR/ADORA2A)-deficient mice (knockout/KO). In vitro, EETs prevented LPS-induced inflammation and apoptosis in the cardiomyocytes via A2AR activation. Moreover, ZM241385 (A2AR inhibitor) attenuated the cardioprotective properties of EETs. Further investigation demonstrated that A2AR signal pathway activation partly regulated phosphatidylinositol 3-kinase (PI3K) and peroxisome proliferator-activated receptor-γ (PPARγ) expression. This is the first report on EETs exerting cardioprotective effects against LPS-induced cardiomyocyte injury via A2AR activation.Copyright © 2021. Published by Elsevier Inc.

基金：
National Natural Science Foundation of China (Nos. 81800329).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 生物
小类 | 4 区 生化与分子生物学 4 区 细胞生物学
最新[2025]版：
大类 | 3 区 生物学
小类 | 4 区 生化与分子生物学 4 区 细胞生物学
JCR分区：
出版当年[2019]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q4 CELL BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者单位： [1]Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, the Second Hospital of Tianjin Medical University, Tianjin, People’s Republic of China
通讯作者：
通讯机构： [1]Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, the Second Hospital of Tianjin Medical University, Tianjin, People’s Republic of China [*1]Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, People’s Republic of China.
推荐引用方式(GB/T 7714)：
yang lei,chen chen,lv bingya,et al.Epoxyeicosatrienoic Acids Prevent Cardiomyocytes against Sepsis by A2AR-induced Activation of PI3K and PPARγ.[J].Prostaglandins & other lipid mediators.2021,157:doi:10.1016/j.prostaglins.2021.106595.
APA：
yang lei,chen chen,lv bingya,gao yi&li guangping.(2021).Epoxyeicosatrienoic Acids Prevent Cardiomyocytes against Sepsis by A2AR-induced Activation of PI3K and PPARγ..Prostaglandins & other lipid mediators,157,
MLA：
yang lei,et al."Epoxyeicosatrienoic Acids Prevent Cardiomyocytes against Sepsis by A2AR-induced Activation of PI3K and PPARγ.".Prostaglandins & other lipid mediators 157.(2021)

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