Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), has been recently considered a systemic disorder leading to the procoagulant state. Preliminary studies have shown that SARS-CoV-2 can infect endothelial cells, and extensive evidence of inflammation and endothelial dysfunction has been found in advanced COVID-19. Endothelial cells play a critical role in many physiological processes, such as controlling blood fluidity, leukocyte activation, adhesion, platelet adhesion and aggregation, and transmigration. Therefore, it is reasonable to think that endothelial dysfunction leads to vascular dysfunction, immune thrombosis, and inflammation associated with COVID-19. This article summarizes the association of endothelial dysfunction and SARS-CoV-2 infection and its therapeutic strategies.
基金：
National Natural Science Foundation of China [81873870]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Div Trauma & Surg Crit Care, Tongji Hosp,Dept Surg, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Deng Hai,Tang Ting-Xuan,Chen Deng,et al.Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies[J].PATHOGENS.2021,10(5):doi:10.3390/pathogens10050582.
APA：
Deng, Hai,Tang, Ting-Xuan,Chen, Deng,Tang, Liang-Sheng,Yang, Xiang-Ping&Tang, Zhao-Hui.(2021).Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies.PATHOGENS,10,(5)
MLA：
Deng, Hai,et al."Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies".PATHOGENS 10..5(2021)
