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Coagulopathy in elderly patients with coronavirus disease 2019.

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单位： [1]The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P. R. China [2]Department of Pulmonary and Critical Care Medicine, Beijing Hospital, National Center of Gerontology. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P. R. China [3]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China

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关键词： aged blood coagulation disorders COVID-19 inflammation

摘要：

Since the outbreak of coronavirus disease 2019 (COVID-19), clinical features have been analyzed in detail. However, coagulopathy in elderly COVID-19 patients has been scarcely reported. Coagulation parameters of 189 patients with COVID-19 in Tongji hospital were retrospectively analyzed among age groups. Patients were divided into 2 groups: older group (≥65 years, n = 87) and younger group (<65 years, n = 102). The proportion of patients with elevated fibrinogen (79.0% vs 59.6%, p = .005) and D-dimer (78.0% vs 55.2%, p = .001) shows the significant difference between the groups. The elderly patients revealed significantly longer prothrombin time (14.0 [13.4-14.4]s vs 13.6 [13.2-14.1]s, p = .026), higher D-dimer (1.00 [0.5-1.9] μg/mL vs 0.6 [0.3-1.6] μg/mL, p = .013) and fibrinogen (5.2 [4.1-6.2] g/L vs 4.4 [3.4-5.7] g/L, p = .004) levels, compared to the younger group. A positive correlation was observed between the coagulation parameters and inflammatory markers including high-sensitivity C-reactive protein and interleukin-6 (p < .05). The hypercoagulable state is more common in elderly COVID-19 patients, and coagulopathy is associated with excessive systemic inflammation. © 2020 The Authors. Aging Medicine published by Beijing Hospital and John Wiley & Sons Australia, Ltd.

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大类 | 4 区医学

小类 | 4 区老年医学

第一作者：

第一作者单位： [1]The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P. R. China

通讯作者：

通讯机构： [1]The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P. R. China [2]Department of Pulmonary and Critical Care Medicine, Beijing Hospital, National Center of Gerontology. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P. R. China [*1]Beijing Hospital, Beijing, China.

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