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A multicenter, prospective, observational study on montelukast monotherapy or montelukast-based combinations treating cough variant asthma

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收录情况： ◇ SCIE

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单位： [1]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China [2]Department of Pulmonary and CriticalCare Medicine, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China [3]Department of Pulmonary and Critical CareMedicine, Shenzhen People’s Hospital, Shenzhen, China [4]Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital ofZhejiang Chinese Medical University, Hangzhou, China [5]Department of Pulmonary and Critical Care Medicine, Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University, Guangzhou, China [6]Department of Pulmonary and Critical Care Medicine, Qingdao Municipal Hospital, Qingdao,China [7]Department of Respiratory, The First Affiliated Hospital of Zhejiang University, Hangzhou, China [8]Department of Pulmonary and CriticalCare Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China [9]Department of Pulmonary and Critical Care Medicine,Daping Hospital, Amy Military Medical University, Chongqing, China [10]Department of Pulmonary and Critical Care Medicine, Tongji HospitalAffiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China [11]Department of Pulmonary and CriticalCare Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China [12]Department of Pulmonary andCritical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China [13]Department of Pulmonary and Critical CareMedicine, Hangzhou First People’s Hospital, Hangzhou, China [14]Global Medical Affairs, Merck Research Laboratories, MSD China, Shanghai,China

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关键词： Asthma control Cough score Cough variant asthma (CVA) Montelukast (MONT)

摘要：

Background: Evidence of treatment against cough variant asthma (CVA) is insufficient for the clinical practice in China. We aimed at evaluating the real-world effectiveness of montelukast (MONT) alone or in combination with low-dose inhaled corticosteroids (ICS) and low-dose ICS plus long-acting beta-2-agonists (LABA) for Chinese CVA patients in a multicentre, prospective, cohort study. Methods: Adult patients diagnosed with CVA defined as chronic cough >8 weeks with a positive bronchial provocation test and normal chest X-ray findings were enrolled at respiratory clinics. Study treatment followed routine clinical practice. The investigators initiated MONT by 10 mg/day alone or in combination with a low-dose ICS +/− LABA and followed up treatment outcomes for 4 weeks. The primary outcome measure was the change in cough score (CS) from baseline. Results: The study enrolled 247 patients (MONT =146, MONT + ICS =38, MONT + ICS/LABA =63). In the primary analysis, the mean change (95% CI) in CS at the end of the study was −1.2 (−1.6, −0.9), −0.9 (−1.5, −0.4), and −1.3 (−1.7, −0.8) in the three groups, respectively. MONT monotherapy had a satisfactory rate of weekly asthma control at the end of the study (83.5%, 95% CI: 75.1%, 89.4%) in the per-protocol analysis. Rates of weekly asthma control were similar in two MONT-based combination regimens (83.9%, 81.4%). Short-acting beta-2-agonist (SABA) user (≥2 times per week) was 16.8% in the MONT group. Conclusions: The real-world effectiveness of MONT alone or in combination with ICS or ICS and LABA was acceptable for CVA short-term control. © Journal of Thoracic Disease. All rights reserved.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 4 区呼吸系统

最新[2025]版：

大类 | 4 区医学

小类 | 4 区呼吸系统

JCR分区：

出版当年[2018]版：

Q3 RESPIRATORY SYSTEM

最新[2024]版：

Q3 RESPIRATORY SYSTEM

影响因子： 1.9 最新[2024版] 2.5 最新五年平均 2.027 出版当年[2018版] 2.233 出版当年五年平均 1.804 出版前一年[2017版] 2.046 出版后一年[2019版]

第一作者：

第一作者单位： [1]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China [*1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, Beijing 100029, China

通讯作者：

通讯机构： [1]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China [*1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, Beijing 100029, China

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A multicenter, prospective, observational study on montelukast monotherapy or montelukast-based combinations treating cough variant asthma

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