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miRNA 146b-5p protects against atherosclerosis by inhibiting vascular smooth muscle cell proliferation and migration

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med,Div Cardiol, Wuhan, Peoples R China [2]Fujian Med Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Fuzhou, Peoples R China

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关键词： atherosclerosis epigenetics inflammation migration miR-146b neointima formation proliferation vascular smooth muscle cells

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Aim:To explore the potentially important role of miRNA 146b-5p (miR-146b) during the development of atherosclerosis.Materials & methods:Proliferation, migration and luciferase assays and mouse models were used to determine the functions of miR-146b.Results:miR-146b was identified as substantially upregulated in the aortic plaques ofApoE-/- mice as well as in response to inflammatory cytokines. Overexpression of miR-146b repressed proliferation and migration of vascular smooth muscle cells by downregulatingBag1andMmp16, respectively. Adeno-associated virus-mediated miR-146b overexpression inhibited neointima formation after carotid injury and suppressed atherosclerotic plaque formation in western diet-inducedApoE-/- mice.Conclusion:miR-146b is a novel regulator of vascular smooth muscle cell function induced by inflammatory response, specifically in neointima formation, and offers a novel therapeutic strategy for treating atherosclerosis.

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出版当年[2019]版：

大类 | 2 区医学

小类 | 2 区遗传学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区遗传学

JCR分区：

出版当年[2018]版：

Q1 GENETICS & HEREDITY

最新[2023]版：

Q2 GENETICS & HEREDITY

影响因子： 3 最新[2023版] 3.4 最新五年平均 4.404 出版当年[2018版] 4.855 出版当年五年平均 4.979 出版前一年[2017版] 4.112 出版后一年[2019版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med,Div Cardiol, Wuhan, Peoples R China

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