单位：[1]Department of Urology, Beijing Hospital, Beijing 100730, China[2]Department of Urology, Beijing Chao-Yang Hospital, Beijing 100730, China.北京朝阳医院[3]Department of Urology, The First Clinical College of Harbin Medical University, Harbin, Heilongjiang 150001, China.[4]Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.[5]Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China.深圳市康宁医院北京大学深圳医院深圳医学信息中心[6]Department of Urology, Nan Fang Hospital, Guangzhou, Guandong 440100, China.[7]Department of Urology, The First Clinical College of Shanxi Medical University, Taiyuan, Shanxi 030012, China.[8]Department of Urology, Southwest Hospital, Chongqing 400038, China.[9]Department of Urology, Peking Union Medical College Hospital, Beijing 100005, China.[10]Department of Urology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China.[11]Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.[12]Department of Urology, Changhai Hospital of Shanghai, Shanghai 200433, China.[13]Department of Urology, Ruijin Hospital Affiliated to The Shanghai Jiaotong University Medical School, Shanghai 200025, China.[14]Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.[15]Department of Urology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.[16]Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.[17]Department of Urology, Peking University People's Hospital, Beijing 100044, China.[18]Department of Urology, The General Hospital of the People's Liberation Army, Beijing 100039, China.[9]Department of Urology, Peking Union Medical College Hospital, Beijing 100005, China.[20]Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China.[21]Department of Urology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.[22]Department of Urology, Wuhan Union Hospital, Wuhan, Hubei 430022, China.华中科技大学同济医学院附属协和医院[23]Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116600, China.大连医科大学附属第一医院[24]Department of Urology,Tongji Hospital,Tongji Medical College Huazhong University of Science,Wuhan,Hubei 430030,China.华中科技大学同济医学院附属同济医院外科学系泌尿外科
Overactive bladder (OAB) is a series of symptoms with high prevalence in elderly people. This study was conducted using the overactive bladder symptom score (OABSS) to evaluate the efficacy of solifenacin succinate for the treatment of OAB.
This was a prospective, multicenter, single-arm, 12-week study that enrolled 241 OAB patients. The patients received 5-10 mg/day solifenacin. Changes in OABSS, symptoms from voiding diary, perception of bladder condition (PPBC) score, international prostate symptom score (IPSS) and quality of life (QOL) were evaluated at weeks 0, 4, and 12. The relationship between OABSS and PPBC score or parameters of voiding diary was also evaluated.
At baseline, the mean OABSS for all patients was 9.41 ± 2.40, and was reduced significantly at week 12 (-3.76 points; 61.21%, P < 0.0001). The OABSS subscore, PPBC score, IPSS, and QOL were also significantly reduced during the study (P < 0.0001). The overall incidence of adverse events was 19.91% (44 cases). The gastrointestinal system was the most commonly affected (11.31%). Around 5.88% of the cases had adverse events related to the genitourinary system. There was a strong correlation between OABSS and urinary symptoms that was recorded in the 3-day voiding dairy.
We showed that solifenacin was clinically effective for relieving OAB symptoms, considering the balance between efficacy, patients' well-being, and tolerability. OABSS integrates four OAB symptoms into a single score and can be a useful tool for research and clinical practice.
第一作者单位：[1]Department of Urology, Beijing Hospital, Beijing 100730, China
通讯作者：
通讯机构：[1]Department of Urology, Beijing Hospital, Beijing 100730, China[*1]Department of Urology, Beijing Hospital, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Liu Ming,Wang Jianye,Yang Yong,et al.Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms.[J].Chinese medical journal.2014,127(2):261-265.doi:10.3760/cma.j.issn.0366-6999.20131349.
APA：
Liu Ming,Wang Jianye,Yang Yong,An Ruihua,Wen Jianguo...&Ye Zhangqun.(2014).Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms..Chinese medical journal,127,(2)
MLA：
Liu Ming,et al."Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms.".Chinese medical journal 127..2(2014):261-265
