详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Contrary regulation of TIMP-1 and MMP-9 by hepatocyte growth factor antibody after lung injury

文献详情

资源类型：

Pubmed体系：

收录情况： ◇ 统计源期刊 ◇ CSCD-C

作者：

单位： [1]Institute of General Department,Huazhong University of Science and Technology,Tongji Hospital,Wuhan 430030,China

出处：

DOI：

ISSN：

关键词： hepatocyte growth factor matrix metalloproteinases-9 tissue inhibitor of metalloproteinases-1

摘要：

Objective: To study the influence of hepatocyte growth factor (HGF) antibody on the lung expression level of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). Methods: Thirty male Wistar rats were randomly divided into 3 groups: control group, model group, and intervention group. Endotoxin was intratracheally infused in the model and intervention groups. HGF antibody was injected in the rats of the intervention group from day 1 to day 14, while the same volume of saline was injected in the control group. The rats were sacrificed on day 28 after endotoxin treatment. The amounts of MMP-9 mRNA and TIMP-1 mRNA were measured by reverse transcription-polymerase chain reaction, and protein expression levels of MMP-9 and TIMP-1 were measured by immunohistochemistry. Results: In the model group, both mRNA and protein expression levels of TIMP-1 were significantly increased, the same as MMP-9. In the intervention group, the increase of TIMP-1 was remarkably reduced compared with the model group, while the mRNA and protein expression levels of MMP-9 were still increased. Conclusion: HGF activity may accelerate the repair of lung injury through contrary regulating the expression levels of TIMP-1 and MMP-9. © 2011 Chinese Academy Medical Sciences.

语种：

PubmedID：

第一作者：

第一作者单位： [1]Institute of General Department,Huazhong University of Science and Technology,Tongji Hospital,Wuhan 430030,China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Expression of matrix metalloproteinases-2,-9 and reversion-inducing cysteine-rich protein with Kazal motifs in gingiva in periodontal health and disease [2]Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α. [3]Hypoxia activated HGF expression in pancreatic stellate cells confers resistance of pancreatic cancer cells to EGFR inhibition [4]肝细胞生长因子在肝星状细胞调控卵圆细胞凋亡中的作用 [5]替米沙坦上调肝细胞生长因子表达的分子机制研究 [6]Mouse mesenchymal stem cells from bone marrow differentiate into smooth muscle cells by induction of plaque-derived smooth muscle cells [7]HSCs play a distinct role in different phases of oval cell-mediated liver regeneration [8]Breast Cancer Associated Fibroblasts Promote MCF-7 Invasion in vitro by Secretion of HGF [9]Cancer-associated fibroblasts promote the stemness of CD24+ liver cells via paracrine signaling [10]便携式一体化腹膜外腔扩张器