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Effect of dezocine administration in the prevention of fentanyl-induced cough during general anesthesia induction: a systematic review and meta-analysis of randomized controlled trials

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单位: [1]Department of Otolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Shanghai, China [2]Departments of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China. [3]Departments of Thyroid-Breast Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China. [4]Departments of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China.
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关键词: Fentanyl induced cough dezocine anesthesia meta-analysis systematic review

摘要:
Objectives: The aim of this study is to evaluate the efficacy and safety of dezocine administration in the prevention of fentanyl induced cough (FIC). Methods: Literature search based on Pubmed, EMBASE, ISI Web of Science, CENTRAL, CNKI was performed to identify potential randomized controlled trials (RCTs) assessing the effect of dezocine in FIC. Two reviewers selected each article independently according to predetermined inclusion criteria. Meta-analysis was conducted via RevMan 5.3. Results: A total of 15 RCTs involving 2074 patients that scheduled for elective surgeries were included, low dose dezocine administration, 0.1 mg/kg dezocine and high dose dezocine were effective in preventing FIC (low dose: RR 0.01 95% CI 0.00, 0.08; 0.1 mg/kg: RR 0.11 95% CI 0.06, 0.17; high dose: RR 0.15 95% CI 0.10, 0.23). The combined incidence of FIC in normal saline groups were around 51%. Subgroup-analysis and sensitivity analysis were performed. Discussion: The results of our study indicated a definite effect of dezocine administration, which is irrespective of the dosage of dezocine injection. Future studies with larger scale and strict design are recommended.

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出版当年[2016]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
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出版当年[2015]版:
Q4 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2024]版:
Q4 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子: 最新[2024版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

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第一作者单位: [1]Department of Otolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Shanghai, China
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通讯机构: [1]Department of Otolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Shanghai, China [2]Departments of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China. [*1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095#,Jie-Fang Avenue,Qiaokou District,Wuhan 430030,Hubei,China. [*2]Department of Otolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Shanghai, China.
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