Effect of dezocine administration in the prevention of fentanyl-induced cough during general anesthesia induction: a systematic review and meta-analysis of randomized controlled trials
单位:[1]Department of Otolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Shanghai, China[2]Departments of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China.华中科技大学同济医学院附属同济医院[3]Departments of Thyroid-Breast Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China.华中科技大学同济医学院附属同济医院[4]Departments of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China.华中科技大学同济医学院附属同济医院耳鼻咽喉-头颈外科
Objectives: The aim of this study is to evaluate the efficacy and safety of dezocine administration in the prevention of fentanyl induced cough (FIC). Methods: Literature search based on Pubmed, EMBASE, ISI Web of Science, CENTRAL, CNKI was performed to identify potential randomized controlled trials (RCTs) assessing the effect of dezocine in FIC. Two reviewers selected each article independently according to predetermined inclusion criteria. Meta-analysis was conducted via RevMan 5.3. Results: A total of 15 RCTs involving 2074 patients that scheduled for elective surgeries were included, low dose dezocine administration, 0.1 mg/kg dezocine and high dose dezocine were effective in preventing FIC (low dose: RR 0.01 95% CI 0.00, 0.08; 0.1 mg/kg: RR 0.11 95% CI 0.06, 0.17; high dose: RR 0.15 95% CI 0.10, 0.23). The combined incidence of FIC in normal saline groups were around 51%. Subgroup-analysis and sensitivity analysis were performed. Discussion: The results of our study indicated a definite effect of dezocine administration, which is irrespective of the dosage of dezocine injection. Future studies with larger scale and strict design are recommended.
基金:
National Natural Science Foundation of China (NSFC) [81670911]
第一作者单位:[1]Department of Otolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Shanghai, China
共同第一作者:
通讯作者:
通讯机构:[1]Department of Otolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Shanghai, China[2]Departments of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China.[*1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095#,Jie-Fang Avenue,Qiaokou District,Wuhan 430030,Hubei,China.[*2]Department of Otolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Shanghai, China.
推荐引用方式(GB/T 7714):
Jiang Wen-Xiu,Huang Jun-Ming,Zhang Jin-Ming,et al.Effect of dezocine administration in the prevention of fentanyl-induced cough during general anesthesia induction: a systematic review and meta-analysis of randomized controlled trials[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2017,10(12):15866-15877.
APA:
Jiang, Wen-Xiu,Huang, Jun-Ming,Zhang, Jin-Ming,Li, Han-Ning,Lu, Xiang...&Lv, Zheng-Tao.(2017).Effect of dezocine administration in the prevention of fentanyl-induced cough during general anesthesia induction: a systematic review and meta-analysis of randomized controlled trials.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,10,(12)
MLA:
Jiang, Wen-Xiu,et al."Effect of dezocine administration in the prevention of fentanyl-induced cough during general anesthesia induction: a systematic review and meta-analysis of randomized controlled trials".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 10..12(2017):15866-15877