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MiR-524 inhibits Cell proliferation and induces cell apoptosis in thyroid cancer via targeting SPAG9

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单位： [a]Department of Otolaryngology, Head and Neck Surgery, Peking University First Hospital, Beijing, China [b]Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [c]Department of Emergency Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [d]Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China

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关键词： Apoptosis MiR-524 Proliferation Thyroid cancer

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OBJECTIVE: To investigate the effect of miR-524 on the proliferation of thyroid cancer and its underlying mechanism. PATIENTS AND METHODS: MiR-524 expression levels in thyroid cancer samples and paracancer tissues were tested by quantitative Real-time polymerase chain reaction (qRT-PCR). Cells proliferative ability and apoptosis were evaluated through methyl thiazolyl tetrazolium (MTT) and apoptosis assays, respectively. Luciferase reporter assay was used to confirm the regulatory mechanism. RESULTS: MiR-524 expression was reduced in thyroid cancer specimen (p<0.05). Up-regulated miR-524 expression inhibited the proliferative ability and enhanced cell apoptosis of thyroid cancer cells. SPAG9 was a target gene of miR-524, and was reversely regulated by miR-524. CONCLUSIONS: MiR-524 represses thyroid cancer cell proliferation and induces cell apoptosis via targeting SPAG9. © 2018 Verduci Editore s.r.l.All Rights Reserved.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区药学

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出版当年[2016]版：

Q3 PHARMACOLOGY & PHARMACY

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影响因子： 0 最新[2024版] 0 最新五年平均 1.778 出版当年[2016版] 1.75 出版当年五年平均 1.575 出版前一年[2015版] 2.387 出版后一年[2017版]

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第一作者单位： [a]Department of Otolaryngology, Head and Neck Surgery, Peking University First Hospital, Beijing, China

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