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Peroxisome proliferator-activated receptor-gamma coactivator-1alpha and dna methylation as epigenetic control (Book Chapter)

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单位： [a]Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [b]Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

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关键词： Bioactive/toxic components in foods Diet DNA methylation Fatty acids Low birth weight Maternal BMI/high-fat diet Maternal hyperglycemia Metabolic disorders Nonalcoholic fatty liver disease Nutrition Obesity Peroxisome proliferator-activated receptor-γ coactivator-1α Type 2 diabetes

摘要：

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is an essential orchestrator in energy homeostasis, serving as a substantial node linking nutritional signals to metabolism. Recent studies indicate that peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) promoter DNA methylation is associated with various disorders and plays an important role in metabolic programming. Dietary and nutritional disequilibrium is recognized as a crucial factor which influences the process of epigenetic modification. In this article, we summarize the current knowledge on the impact of both prenatal and postnatal nutritional factors on the peroxisome proliferatoractivated receptor-γ coactivator-1α (PGC-1α) DNA methylation and their relationship to metabolic disorders, and discuss the unresolved questions that warrant further research. © Springer Nature Switzerland AG 2019. All rights reserved.

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第一作者：

第一作者单位： [a]Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [b]Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

通讯作者：

通讯机构： [a]Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [b]Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

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