Commercially pure titanium (cp-Ti) is widely used in the field of long-term clinical oral implantology owing to its ability to allow close bone-implant apposition. The optimization of its function based on artificial proteins has become a key issue in the development of improved cp-Ti implants. Here, we set out to identify peptide aptamers with preferential adsorption towards titanium-based implants through the phage display methodology. Fifteen sequences were selected in the third round of biopanning. One sequence, ATWVSPY (named TBP1), had a 40% repetition rate and exhibited the strongest binding affinity to cp-Ti disks. Ten sequences were selected in the fourth round, among which the repetition rate is 80% for TBP1 and 20% for TBP2 (GVGLPHT). The peptide aptamers against cp-Ti disks can provide an alternative method of functional coating for biomaterial surfaces.
第一作者单位：[1]Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Yan,Mao Jing,Zhou Bin,et al.Peptide aptamers against titanium-based implants identified through phage display[J].JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE.2010,21(4):1103-1107.doi:10.1007/s10856-009-3970-3.
APA：
Liu, Yan,Mao, Jing,Zhou, Bin,Wei, Wei&Gong, Shiqiang.(2010).Peptide aptamers against titanium-based implants identified through phage display.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,21,(4)
MLA：
Liu, Yan,et al."Peptide aptamers against titanium-based implants identified through phage display".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 21..4(2010):1103-1107
