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Cisplatin Augments FAS-mediated Apoptosis through Lipid Rafts

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单位： [1]Kanazawa Med Univ, Dept Hematol & Immunol, Uchinada, Ishikawa 9200293, Japan [2]Kanazawa Med Univ, Dept Med Oncol, Uchinada, Ishikawa 9200293, Japan [3]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Rheumatol, Wuhan 430030, Hubei, Peoples R China [4]Tottori Univ, Fac Med, Tottori 6838504, Japan

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关键词： Cisplatin FAS apoptosis sphingomyelin lipid rafts

摘要：

Cisplatin is widely and effectively used for the treatment of various types of cancer. However, its biochemical mechanisms are still unelucidated. Previously, we reported that membrane sphingomyelin (SM) was important for FAS-mediated apoptosis through lipid raft function. In this study, we strikingly show that cisplatin combined with CH11 (anti-FAS antibody, IgM) was able to induce marked apoptosis in SM synthase-restored WR/Fas-SMS1 cells, but not in SM synthase-deficient WR/FAS-SM(-) cells. In addition, we demonstrated that membrane SM played an important role in cisplatin/CH11-induced apoptosis through the classical caspase-dependent pathway, mainly by enhancing the formation of FAS-associated signaling complexes.

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出版当年[2009]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2008]版：

Q4 ONCOLOGY

最新[2023]版：

Q4 ONCOLOGY

影响因子： 1.6 最新[2023版] 1.8 最新五年平均 1.39 出版当年[2008版] 1.472 出版当年五年平均 1.414 出版前一年[2007版] 1.428 出版后一年[2009版]

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第一作者单位： [1]Kanazawa Med Univ, Dept Hematol & Immunol, Uchinada, Ishikawa 9200293, Japan

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通讯机构： [1]Kanazawa Med Univ, Dept Hematol & Immunol, Uchinada, Ishikawa 9200293, Japan [*1]Kanazawa Med Univ, Dept Hematol & Immunol, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan

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