Chronic heart failure (CHF) is characterized by diminished cardiac output and pooling of blood in the venous system. Using transcriptome data, we constructed a regulation network to identify the potential genes that related to heart failure. In the network, some of transcription factors and its' target genes have been proved to be related to heart failure in previous study. According to the regulation network, we found some new transcription factors and target genes, which have not been proved to be directly related with; we also found MYC, TP53 and ETS2 regulate each other. Our work demonstrated that regulation of network analysis is useful in identification of the candidate genes in heart failure.
第一作者单位：[1]Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430060, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wu Gang,Xie Qiang,Cheng Mian,et al.Identify potential chronic heart failure related transcription factors by network analysis[J].AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH.2011,5(23):3862-3869.
APA：
Wu Gang,Xie Qiang,Cheng Mian,Jiang Xuejun,Yang Bo&Huang He.(2011).Identify potential chronic heart failure related transcription factors by network analysis.AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH,5,(23)
MLA：
Wu Gang,et al."Identify potential chronic heart failure related transcription factors by network analysis".AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH 5..23(2011):3862-3869
