单位：[1]Experimental Medicine Center of Tongji Hospital[2]Pharmacy of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,People's Republic of China华中科技大学同济医学院附属同济医院药学部[3]Institute of Brain Research,University of Tuebingen,Calwer Str. 3,D-72076 Tuebingen,Germany华中科技大学同济医学院附属同济医院[4]Institute of Immunology, Third Military Medical University of PLA, Gaotanyan Main Street 30, Chongqing, 400038, People's Republic of China
Aptamers are nonnaturally occurring oligonucleotides generated by the SELEX (Systematic Evolution of Ligands by Exponential enrichment) process. Due to their unique three-dimensional structures, aptamers can bind to various targets, ranging from small compounds to cells and tissues, with high affinity and specificity. While first reported in 1990, aptamers have become useful tools in the biomedical field because of their unique characteristics, such as easy and quick preparation, cost-effectiveness, small size, versatility, et al. Recently various chemical modifications have been introduced to enhance aptamers' stability in the body fluids and their bioavailability in animals, which have pushed aptamer closer to therapeutic and diagnostic application. This review provides an overview of the aptamer modifications and their application in the nervous system disorders.
基金：
NSFCNational Natural Science Foundation of China (NSFC) [30700701, 81070954]
第一作者单位：[3]Institute of Brain Research,University of Tuebingen,Calwer Str. 3,D-72076 Tuebingen,Germany
通讯作者：
通讯机构：[1]Experimental Medicine Center of Tongji Hospital[*1]Third Military Medical University of PLA, Gaotanyan Main Street 30, Chongqing, 400038, People's Republic of China
推荐引用方式(GB/T 7714)：
Yang Y.,Ren X.,Schluesener H. J.,et al.Aptamers: Selection, Modification and Application to Nervous System Diseases[J].CURRENT MEDICINAL CHEMISTRY.2011,18(27):4159-4168.doi:10.2174/092986711797189646.
APA：
Yang, Y.,Ren, X.,Schluesener, H. J.&Zhang, Z..(2011).Aptamers: Selection, Modification and Application to Nervous System Diseases.CURRENT MEDICINAL CHEMISTRY,18,(27)
MLA：
Yang, Y.,et al."Aptamers: Selection, Modification and Application to Nervous System Diseases".CURRENT MEDICINAL CHEMISTRY 18..27(2011):4159-4168
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