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Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-kappa B and AP-1 pathway in vitro

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收录情况： ◇ SCIE

作者：
Shuanglin LIU[1,2] * ; Zhihua WANG[1] ; Zhiquan HU[1] ; Xing ZENG[1] ; Youyuan LI[1] ; Yaowu SU[3] ; Chuanhua Zhang[2] ; Zhangqun YE[1] ;
单位： [1]Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Department of Urology, Wuhan First Hospital, Wuhan 430022, China [3]Department of Urology, Beilun People’s Hospital, Ningbo 315000, China
出处：
DOI： 10.1007/s11596-011-0485-1
ISSN：

关键词： curcumin androgen-independent prostate cancer NF-kappa B AP-1

摘要：
The anti-tumor activity of curcumin against androgen-independent prostate cancer cells in vitro and the possible mechanism were investigated. After curcumin treatment, the effect of curcumin on the proliferation of prostate cancer PC-3 cells was assessed by CFSE staining. Flow cytometery (FCM) was performed to analyze the cell cycle and the induction of apoptosis of tumor cells. A luciferase reporter gene assay was used to determine the effects of curcumin on the activities of intracellular NF-kappa B and AP-1 signaling pathways. The results showed curcumin could effectively inhibit the proliferation of PC-3 cells in vitro (P < 0.05). Cells were arrested at G(2)/M phase. After curcumin treatment, the percentage of apoptotic cells was significantly higher than in control group (P < 0.05). The results of the luciferase assay revealed that curcumin selectively inhibited the activities of the NF-kappa B and AP-1 signaling pathways in PC-3 cells significantly. It was suggested that curcumin could exert anti-tumor activity against androgen-independent prostate cancer cells in vitro by inhibiting cellular proliferation and inducing apoptosis, which was probably contributed to the inhibition of transcription factors NF-kappa B and AP-1.

基金：
This project was supported by a grant from the Specialized Research Fund for the Doctoral Program of Higher Education of China (No. 20090142120096).
语种：
外文
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中科院(CAS)分区：
出版当年[2010]版：
大类 | 4 区 医学
小类 | 4 区 生化与分子生物学
最新[2025]版：
无
JCR分区：
出版当年[2009]版：
Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2024]版：
无

影响因子： 最新[2024版] 最新五年平均 出版当年[2009版] 出版当年五年平均 出版前一年[2008版] 出版后一年[2010版]

第一作者：
第一作者单位： [1]Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Department of Urology, Wuhan First Hospital, Wuhan 430022, China
通讯作者：
推荐引用方式(GB/T 7714)：
Shuanglin LIU,Zhihua WANG,Zhiquan HU,et al.Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-kappa B and AP-1 pathway in vitro[J].JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES.2011,31(4):530-534.doi:10.1007/s11596-011-0485-1.
APA：
Shuanglin LIU,Zhihua WANG,Zhiquan HU,Xing ZENG,Youyuan LI...&Zhangqun YE.(2011).Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-kappa B and AP-1 pathway in vitro.JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES,31,(4)
MLA：
Shuanglin LIU,et al."Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-kappa B and AP-1 pathway in vitro".JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 31..4(2011):530-534

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