Recent genome-wide association (GWA) studies have identified two intergenic single nucleotide polymorphisms (SNPs) (rs11833579 and rs12425791) on chromosome 12p13 and within 11 kb of the NINJ2 gene that were significantly associated with stroke in Caucasians. However, the validity of the association has remained controversial. We performed genetic association analyses in three independent cohorts, including total of 3042 cases and 2973 controls. No significant association between these two SNPs and ischemic stroke was detected by meta-analysis after adjustment for cardiovascular risk factors under the additive model. Our data does not support that the common variants on 12p13 are major contributors of ischemic stroke in the Chinese Han population. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
基金:
National "863" projects [2006AA02A406]; "973" project [2007CB512002, 2007CB512004]; Hubei Province Natural Science Key Program [2008CDA047]
第一作者单位:[2]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Internal Med,Wuhan 430074,Peoples R China[4]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Inst Hypertens,Wuhan 430074,Peoples R China
通讯作者:
通讯机构:[1]Huazhong Univ Sci & Technol, Key Lab Mol Biophys, Minist Educ, Coll Life Sci & Technol,Cardiox Ctr, Wuhan 430074, Peoples R China[3]Huazhong Univ Sci & Technol, Ctr Human Genome Res, Wuhan 430074, Peoples R China
推荐引用方式(GB/T 7714):
Ding Hu,Tu Xin,Xu Yujun,et al.No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population[J].ATHEROSCLEROSIS.2011,216(2):381-382.doi:10.1016/j.atherosclerosis.2011.02.005.
APA:
Ding, Hu,Tu, Xin,Xu, Yujun,Xu, Chenqi,Wang, Xiaojing...&Wang, Dao Wen.(2011).No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.ATHEROSCLEROSIS,216,(2)
MLA:
Ding, Hu,et al."No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population".ATHEROSCLEROSIS 216..2(2011):381-382