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Chinese Herbal Medicine in the Treatment of Nonalcoholic Fatty Liver Disease

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单位: [1]Huazhong Univ Sci & Technol,Tongji Med Coll,Inst Integrat Tradit Chinese & Western Med,Tongji Hosp,Wuhan 430030,Peoples R China
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关键词: nonalcoholic fatty liver disease Chinese herbal medicine

摘要:
Chinese herbal medicine has developed new therapies for nonalcoholic fatty liver disease (NAFLD) based on its unique theory system and substantial herb remedies. In this review, 21 traditional Chinese herbs were introduced for their potential benefit in the treatment of NAFLD. Majority of them are evaluated by experimental studies and few by multicenter clinical trials. Herbal monomers as berberine and resveratrol, extracts from Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (sic), YCHD), Qushi Huayu Decoction (sic), QSHYD), and Danning Tablet) were discussed in detail on their therapeutic potentials. Most of these herbal medicines were proved to improve biochemical and histological changes of NAFLD both in vitro and in vivo. Also, their therapeutic activities were associated with inhibiting lipid accumulation through adenosine monophosphate-activated protein kinase activation or upregulating low-density lipoprotein receptor (LDLR) expression, alleviating lipid peroxidation, and reducing the production of inflammatory cytokines. Although the efficacy and safety of these herbal medicines needed to be evaluated in multicenter large-scale clinical trials, Chinese medicine is promising and effective for preventing and treating NAFLD disease.

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基金编号: 30772853 30801492

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出版当年[2011]版:
大类 | 4 区 医学
小类 | 4 区 全科医学与补充医学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 全科医学与补充医学
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出版当年[2010]版:
Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE
最新[2023]版:
Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

影响因子: 最新[2023版] 最新五年平均 出版当年[2010版] 出版当年五年平均 出版前一年[2009版] 出版后一年[2011版]

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第一作者单位: [1]Huazhong Univ Sci & Technol,Tongji Med Coll,Inst Integrat Tradit Chinese & Western Med,Tongji Hosp,Wuhan 430030,Peoples R China
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