单位:[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Inst Integrat Tradit Chinese & Western Med,Tongji Hosp,Wuhan 430030,Peoples R China华中科技大学同济医学院附属同济医院中西医结合研究所
Chinese herbal medicine has developed new therapies for nonalcoholic fatty liver disease (NAFLD) based on its unique theory system and substantial herb remedies. In this review, 21 traditional Chinese herbs were introduced for their potential benefit in the treatment of NAFLD. Majority of them are evaluated by experimental studies and few by multicenter clinical trials. Herbal monomers as berberine and resveratrol, extracts from Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (sic), YCHD), Qushi Huayu Decoction (sic), QSHYD), and Danning Tablet) were discussed in detail on their therapeutic potentials. Most of these herbal medicines were proved to improve biochemical and histological changes of NAFLD both in vitro and in vivo. Also, their therapeutic activities were associated with inhibiting lipid accumulation through adenosine monophosphate-activated protein kinase activation or upregulating low-density lipoprotein receptor (LDLR) expression, alleviating lipid peroxidation, and reducing the production of inflammatory cytokines. Although the efficacy and safety of these herbal medicines needed to be evaluated in multicenter large-scale clinical trials, Chinese medicine is promising and effective for preventing and treating NAFLD disease.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30772853, 30801492]
第一作者单位:[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Inst Integrat Tradit Chinese & Western Med,Tongji Hosp,Wuhan 430030,Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
dong hui,lu fu-er,zhao li.Chinese Herbal Medicine in the Treatment of Nonalcoholic Fatty Liver Disease[J].CHINESE JOURNAL OF INTEGRATIVE MEDICINE.2012,18(2):152-160.doi:10.1007/s11655-012-0993-2.
APA:
dong hui,lu fu-er&zhao li.(2012).Chinese Herbal Medicine in the Treatment of Nonalcoholic Fatty Liver Disease.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,18,(2)
MLA:
dong hui,et al."Chinese Herbal Medicine in the Treatment of Nonalcoholic Fatty Liver Disease".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 18..2(2012):152-160