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MITOCHONDRIAL NITRIC OXIDE SYNTHASE PARTICIPATES IN SEPTIC SHOCK MYOCARDIAL DEPRESSION BY NITRIC OXIDE OVERPRODUCTION AND MITOCHONDRIAL PERMEABILITY TRANSITION PORE OPENING

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单位： [1]Zhejiang Univ, Sch Med, Dept Physiol, Hangzhou 310058, Zhejiang, Peoples R China [2]Sichuan Univ, W China Hosp, Natl Chengdu Ctr Safety Evaluat Drugs, Chengdu 610064, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430074, Peoples R China

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关键词： Septic shock cecal ligation and puncture mitochondrial nitric oxide synthase mitochondrial permeability transition pore

摘要：

The aim of this study was to determine whether mitochondrial nitric oxide (NO) synthase (NOS) is involved in septic shock myocardial depression. The cecal ligation and puncture (CLP) method was used to induce septic shock. There was a significant depression of hemodynamic parameters recorded in the septic shock stage. After using nonselective NOS inhibitor N-nitro-L-arginine methyl ester (L-NAME), inducible NOS inhibitor aminoguanidine (AMG), and neuronal NOS inhibitor 7-nitroindazole (7-NI), depression of the parameters was partly attenuated. Nitric oxide production in isolated cardiac mitochondria increased obviously in the CLPYseptic shock stage, L-NAME and 7-NI both decreased NO production significantly. Nitrite/nitrate (NOx-) production in the septic shock stage was much greater than those in the corresponding sham groups, and NOx- production in the cytosol by inducible NOS was greater. Treatment with AMG suppressed NOx- production in the cytosol by iNOS, whereas treatment with 7-NI decreased NOx- production in the mitochondria. Mitochondrial NOS expression increased significantly in the septic shock stage, and its overexpression was attenuated using 7-NI. There was no significant decrease in the mitochondrial permeability transition pore measurement in the CLPYseptic shock group, whereas a significant decrease was observed in those treated with L-NAME or 7-NI. These results indicate that overexpression of mitochondrial NOS is involved in myocardial depression.

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出版当年[2011]版：

大类 | 3 区医学

小类 | 2 区外科 3 区危重病医学 3 区血液学 3 区外周血管病

最新[2025]版：

大类 | 3 区医学

小类 | 3 区血液学 3 区外周血管病 3 区外科 4 区危重病医学

JCR分区：

出版当年[2010]版：

Q1 PERIPHERAL VASCULAR DISEASE Q1 SURGERY Q2 HEMATOLOGY Q2 CRITICAL CARE MEDICINE

最新[2023]版：

Q1 SURGERY Q2 CRITICAL CARE MEDICINE Q2 HEMATOLOGY Q2 PERIPHERAL VASCULAR DISEASE

影响因子： 2.7 最新[2023版] 2.8 最新五年平均 3.203 出版当年[2010版] 3.395 出版当年五年平均 2.871 出版前一年[2009版] 2.848 出版后一年[2011版]

第一作者：

第一作者单位： [1]Zhejiang Univ, Sch Med, Dept Physiol, Hangzhou 310058, Zhejiang, Peoples R China [2]Sichuan Univ, W China Hosp, Natl Chengdu Ctr Safety Evaluat Drugs, Chengdu 610064, Peoples R China

通讯作者：

通讯机构： [1]Zhejiang Univ, Sch Med, Dept Physiol, Hangzhou 310058, Zhejiang, Peoples R China [*1]Zhejiang Univ, Sch Med, Dept Physiol, 388 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

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