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Involvement of cationic channels in proliferation and migration of human mesenchymal stem cells

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WOS体系：
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收录情况： ◇ SCIE

作者：
Ding, Fengfei[1,3] * ; Zhang, Guibing[2] ; Liu, Lu[3] ; Jiang, Lizhong[1] ; Wang, Rui[3] ; Zheng, Yunjie[4] ; Wang, Guoping[1] ; Xie, Minjie[3,*1] ; Duan, Yaqi[1] ;
单位： [1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Pathol,Wuhan 430074,Peoples R China [2]Hubei Univ Med, Xiangyang Hosp Affiliated, Dept Neurol, Xiangyang, Hubei, Peoples R China [3]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Neurol,Wuhan 430074,Peoples R China [4]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Physiol, Wuhan 430074, Peoples R China
出处：
DOI： 10.1016/j.tice.2012.06.001
ISSN：

关键词： Human mesenchymal stem cells K+ channels Proliferation Migration

摘要：
Human mesenchymal stem cells (HMSCs) have been applied in various clinic settings. Ion channels play an important role in cellular physiology. However, the potential role of cationic channels in regulating the proliferation and migration properties of hMSCs remains to be determined. In the present study, the functional expression of ion channels in hMSCs was investigated by patch clamp. MTT assay and BrdU stainings were used to assess the proliferation of hMSCs. hMSC migration was evaluated by Transwell migration assays. The results show that sodium-, L-type calcium, potassium currents have been identified in hMSCs. TEA (K+ channel blocker), nifedipine (Ca2+ channel blocker) can inhibit both proliferation and migration of hMSCs. The increase of extracellular Ca2+ concentration promoted both proliferation and migration of hMSCs. TTX, a Na+ channel blocker, promoted cell proliferation but inhibited cell migration. Our data suggest that cationic channels (sodium, L-type calcium, potassium channels) play important roles in regulating proliferation and migration of hMSCs. (c) 2012 Elsevier Ltd. All rights reserved.

基金：
National Natural Science Foundation of China [30400153, 30971007]; Natural Science Foundation of Hubei Province for outstanding young scholars [2010CDA103]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2011]版：
大类 | 4 区 医学
小类 | 4 区 解剖学与形态学 4 区 细胞生物学
最新[2025]版：
大类 | 3 区 生物学
小类 | 3 区 解剖学与形态学 4 区 细胞生物学
JCR分区：
出版当年[2010]版：
Q2 ANATOMY & MORPHOLOGY Q4 CELL BIOLOGY
最新[2023]版：
Q1 ANATOMY & MORPHOLOGY Q3 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2010版] 出版当年五年平均 出版前一年[2009版] 出版后一年[2011版]

第一作者：
第一作者单位： [1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Pathol,Wuhan 430074,Peoples R China [3]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Neurol,Wuhan 430074,Peoples R China
通讯作者：
通讯机构： [3]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Neurol,Wuhan 430074,Peoples R China [*1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Neurol,Hangkong Rd 13,Wuhan 430074,Peoples R China
推荐引用方式(GB/T 7714)：
Ding Fengfei,Zhang Guibing,Liu Lu,et al.Involvement of cationic channels in proliferation and migration of human mesenchymal stem cells[J].TISSUE & CELL.2012,44(6):358-364.doi:10.1016/j.tice.2012.06.001.
APA：
Ding, Fengfei,Zhang, Guibing,Liu, Lu,Jiang, Lizhong,Wang, Rui...&Duan, Yaqi.(2012).Involvement of cationic channels in proliferation and migration of human mesenchymal stem cells.TISSUE & CELL,44,(6)
MLA：
Ding, Fengfei,et al."Involvement of cationic channels in proliferation and migration of human mesenchymal stem cells".TISSUE & CELL 44..6(2012):358-364

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