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A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Li, Yongzhe[1,2] * ; Zhang, Kunlin[3] ; Chen, Hua[1,2] ; Sun, Fei[1,2] ; Xu, Juanjuan[1,2] ; Wu, Ziyan[1,2] ; Li, Ping[1,2] ; Zhang, Liuyan[3] ; Du, Yang[3] ; Luan, Haixia[1,2] ; Li, Xi[1,2] ; Wu, Lijun[4] ; Li, Hongbin[5] ; Wu, Huaxiang[6] ; Li, Xiangpei[7] ; Li, Xiaomei[7] ; Zhang, Xiao[8] ; Gong, Lu[9] ; Dai, Lie[10] ; Sun, Lingyun[11] ; Zuo, Xiaoxia[12] ; Xu, Jianhua[13] ; Gong, Huiping[14] ; Li, Zhijun[15] ; Tong, Shengquan[16] ; Wu, Min[17] ; Li, Xiaofeng[18] ; Xiao, Weiguo[19] ; Wang, Guochun[20] ; Zhu, Ping[21] ; Shen, Min[1,2] ; Liu, Shengyun[22] ; Zhao, Dongbao[23] ; Liu, Wei[24] ; Wang, Yi[25] ; Huang, Cibo[26] ; Jiang, Quan[27] ; Liu, Guijian[28] ; Liu, Bin[29] ; Hu, Shaoxian[30] ; Zhang, Wen[1,2] ; Zhang, Zhuoli[31] ; You, Xin[1,2] ; Li, Mengtao[1,2] ; Hao, Weixin[32,33] ; Zhao, Cheng[34] ; Leng, Xiaomei[1,2] ; Bi, Liqi[35] ; Wang, Yongfu[36] ; Zhang, Fengxiao[37] ; Shi, Qun[1,2] ; Qi, Wencheng[38] ; Zhang, Xuewu[39] ; Jia, Yuan[39] ; Su, Jinmei[1,2] ; Li, Qin[40] ; Hou, Yong[1,2] ; Wu, Qingjun[1,2] ; Xu, Dong[1,2] ; Zheng, Wenjie[1,2] ; Zhang, Miaojia[41] ; Wang, Qian[1,2] ; Fei, Yunyun[1,2] ; Zhang, Xuan[1,2] ; Li, Jing[1,2] ; Jiang, Ying[1,2] ; Tian, Xinping[1,2] ; Zhao, Lidan[1,2] ; Wang, Li[1,2] ; Zhou, Bin[42,43] ; Li, Yang[44] ; Zhao, Yan[1,2] ; Zeng, Xiaofeng[1,2] ; Ott, Jurg[3] ; Wang, Jing[3] ; Zhang, Fengchun[1,2] ;
单位： [1]Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing 100021, Peoples R China [2]Chinese Acad Med Sci, Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing 100730, Peoples R China [3]Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China [4]Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Rheumatol & Immunol, Urumqi, Peoples R China [5]Inner Mongolia Med Coll, Affiliated Hosp, Dept Rheumatol, Hohhot, Peoples R China [6]Zhejiang Univ, Affiliated Hosp 2, Coll Med, Dept Rheumatol, Hangzhou 310027, Zhejiang, Peoples R China [7]Anhui Med Univ, Affiliated Anhui Prov Hosp, Dept Rheumatol & Immun, Hefei, Peoples R China [8]Guangdong Acad Med Sci, Guangdong Gen Hosp, Dept Rheumatol & Immunol, Guangzhou, Guangdong, Peoples R China [9]Tianjin Med Univ, Gen Hosp, Dept Immunol, Tianjin, Peoples R China [10]Sun Yat Sen Univ, SUN Yat Sen Mem Hosp, Dept Rheumatol, Guangzhou 510275, Guangdong, Peoples R China [11]Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Rheumatol & Immunol, Nanjing 210008, Jiangsu, Peoples R China [12]Cent South Univ, Xiangya Hosp, Dept Rheumatol & Immunol, Changsha 410083, Peoples R China [13]Anhui Med Univ, Affiliated Hosp 1, Dept Rheumatol, Hefei, Peoples R China [14]Changzhi Med Coll, Affiliated Heping Hosp, Dept Rheumatol & Immunol, Changzhi, Peoples R China [15]Bengbu Med Coll, Affiliated Hosp 1, Dept Rheumatol & Immunol, Bengbu, Peoples R China [16]Tangshan Gongren Hosp, Dept Rheumatol & Immunol, Tangshan, Peoples R China [17]First Peoples Hosp Changzhou, Dept Rheumatol & Immunol, Changzhou, Peoples R China [18]Shanxi Med Univ Second Hosp, Dept Rheumatol & Immunol, Taiyuan, Peoples R China [19]China Med Univ, Hosp 1, Dept Rheumatol, Shenyang, Peoples R China [20]China Japan Friendship Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China [21]Fourth Mil Med Univ, Xijing Hosp, Dept Rheumatol & Immunol, Xian 710032, Peoples R China [22]Zhengzhou Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Zhengzhou 450052, Peoples R China [23]Second Mil Med Univ, Changhai Hosp, Dept Rheumatol & Immunol, Shanghai, Peoples R China [24]Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Dept Rheumatol & Immunol, Tianjin, Peoples R China [25]Lanzhou Univ, Hosp 2, Dept Rheumatol & Immunol, Lanzhou 730000, Peoples R China [26]Beijing Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China [27]China Acad Chinese Med Sci, Guanganmen Hosp, Dept Rheumatol, Beijing, Peoples R China [28]China Acad Chinese Med Sci, Guanganmen Hosp, Dept Lab, Beijing, Peoples R China [29]Qingdao Univ, Affiliated Hosp, Coll Med, Dept Rheumatol & Immunol, Qingdao 266071, Peoples R China [30]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Immunol & Rheumatol, Wuhan 430074, Peoples R China [31]Peking Univ, Hosp 1, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China [32]Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Tradit Chinese Med, Beijing 100021, Peoples R China [33]Chinese Acad Med Sci, Beijing 100730, Peoples R China [34]Guangxi Med Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Nanning, Peoples R China [35]Jilin Univ, China Japan Union Hosp, Dept Rheumatol & Immunol, Changchun 130023, Peoples R China [36]Baotou Med Coll, Affiliated Hosp 1, Dept Rheumatol & Immunol, Baotou, Peoples R China [37]Hebei Peoples Hosp, Dept Rheumatol & Immunol, Shijiazhuang, Peoples R China [38]Tianjin First Cent Hosp, Dept Rheumatol & Immunol, Tianjin, Peoples R China [39]Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China [40]Yunnan Univ, Peoples Hosp 1, Dept Rheumatol & Immunol, Kunming, Peoples R China [41]Jiangsu Prov Peoples Hosp, Dept Rheumatol, Nanjing, Jiangsu, Peoples R China [42]Sichuan Acad Med Sci, Dept Rheumatol & Immunol, Chengdu, Peoples R China [43]Sichuan Prov Peoples Hosp, Chengdu, Peoples R China [44]Harbin Med Univ, Affiliated Hosp 2, Dept Rheumatol & Immunol, Harbin, Peoples R China
出处：
DOI： 10.1038/ng.2779
ISSN：

摘要：
Primary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjogren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjogren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: P-combined = 1.31 x 10(-53), combined odds ratio (ORcombined) = 2.20) as a new susceptibility locus for primary Sjogren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1-GTF2I.

基金：
Research Special Fund for Public Welfare Industry of Health [201202004]; National Science Technology Pillar Program in the 11th Five-Year Plan [2008BAI59B03]; National Program on Key Research Project of New Drug Innovation [2012ZX09303006-002]; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-J-8]; CAS/SAFEA International Partnership Program for Creative Research Teams [Y2CX131003]; National Natural Science Foundation of China [81072486, 81172857, 81101545]

基金编号： 201202004 2008BAI59B03 2012ZX09303006-002 KSCX2-EW-J-8 Y2CX131003 81072486 81172857 81101545

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2012]版：
大类 | 1 区 生物
小类 | 1 区 遗传学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 遗传学
JCR分区：
出版当年[2011]版：
Q1 GENETICS & HEREDITY
最新[2024]版：
Q1 GENETICS & HEREDITY

影响因子： 最新[2024版] 最新五年平均 出版当年[2011版] 出版当年五年平均 出版前一年[2010版] 出版后一年[2012版]

第一作者：
第一作者单位： [1]Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing 100021, Peoples R China [2]Chinese Acad Med Sci, Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing 100730, Peoples R China
通讯作者：
通讯机构： [1]Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing 100021, Peoples R China [2]Chinese Acad Med Sci, Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714)：
Li Yongzhe,Zhang Kunlin,Chen Hua,et al.A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23[J].NATURE GENETICS.2013,45(11):1361-+.doi:10.1038/ng.2779.
APA：
Li, Yongzhe,Zhang, Kunlin,Chen, Hua,Sun, Fei,Xu, Juanjuan...&Zhang, Fengchun.(2013).A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23.NATURE GENETICS,45,(11)
MLA：
Li, Yongzhe,et al."A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23".NATURE GENETICS 45..11(2013):1361-+

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