The translocation t(15;17), which results in the PML-RAR alpha fusion gene, is a characteristic chromosomal translocation in acute promyelocytic leukemia (APL). But additional chromosome aberrations in APL are increasingly recognized. Here, we report on a 16-year-old APL patient who had an fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) and a 46,XY,t(15;17)(q22;q21)-16+mar karyotype at diagnosis. The patient achieved complete remission after induction therapy with all-trans retinoic acid and chemotherapy. But he soon relapsed presenting distinctive APL features in the bone marrow and leptomeninges and showing a chromosome translocation change involving chromosomes 7 and 16 besides t(15;17)(q22;q21). The new karyotype 46, XY,t(7;16) (q31;q22),t(15;17)(q22;q21) was determined. To the best of our knowledge, this is the first report of a de novo APL with a chromosome translocation t(7; 16)(q31,q22) together with a t(15;17)(q22;q21) and FLT3-ITD mutation. Copyright (c) 2013 S. Karger AG, Basel
基金：
National Science Foundation of China [81270599, 81001049]
第一作者单位：[1]Huazhong Univ Sci & Technol, Dept Hematol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Cao Y.,Yuan R.,Wang Y.,et al.A New Chromosome Translocation t(7;16)(q31,q22) Change during an Acute Promyelocytic Leukemia Relapse[J].CYTOGENETIC AND GENOME RESEARCH.2013,141(1):70-74.doi:10.1159/000350871.
APA：
Cao, Y.,Yuan, R.,Wang, Y.,Chen, R.,Huang, M.&Zhou, J..(2013).A New Chromosome Translocation t(7;16)(q31,q22) Change during an Acute Promyelocytic Leukemia Relapse.CYTOGENETIC AND GENOME RESEARCH,141,(1)
MLA：
Cao, Y.,et al."A New Chromosome Translocation t(7;16)(q31,q22) Change during an Acute Promyelocytic Leukemia Relapse".CYTOGENETIC AND GENOME RESEARCH 141..1(2013):70-74
