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A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Shi, Yongyong[1,2,3,4,5] * ; Li, Li[6] ; Hu, Zhibin[7,8] ; Li, Shuang[1] ; Wang, Shixuan[1] ; Liu, Jihong[9] ; Wu, Chen[10,11] ; He, Lin[2,3,4,5] ; Zhou, Jianfeng[12] ; Li, Zhiqiang[2,3,4,5] ; Hu, Ting[1] ; Chen, Yile[13] ; Jia, Yao[1] ; Wang, Shaoshuai[1] ; Wu, Li[13] ; Cheng, Xiaodong[14] ; Yang, Zhijun[6] ; Yang, Ru[1] ; Li, Xiong[1] ; Huang, Kecheng[1] ; Zhang, Qinghua[1] ; Zhou, Hang[1] ; Tang, Fangxu[1] ; Chen, Zhilan[1] ; Shen, Jian[1] ; Jiang, Jie[7,8] ; Ding, Hu[12] ; Xing, Hui[15] ; Zhang, Shulan[16] ; Qu, Pengpeng[17] ; Song, Xiaojie[18] ; Lin, Zhongqiu[19] ; Deng, Dongrui[1] ; Xi, Ling[1] ; Lv, Weiguo[14] ; Han, Xiaobing[20] ; Tao, Guangshi[21] ; Yan, Lixing[22] ; Han, Zhedong[22] ; Li, Zhuang[6] ; Miao, Xiaoping[23] ; Pan, Shandong[7,8] ; Shen, Yuanming[14] ; Wang, Hui[1] ; Liu, Dan[1] ; Gong, Ee[1] ; Li, Zheng[9] ; Zhou, Limei[17] ; Luan, Xiaomei[16] ; Wang, Chuping[24] ; Song, Qian[25] ; Wu, Sufang[26] ; Xu, Hongbin[27] ; Shen, Jiawei[2,3,4,5] ; Qiang, Fulin[28] ; Ma, Gang[29] ; Liu, Li[28] ; Chen, Xiaojun[28] ; Liu, Jibin[28] ; Wu, Jiangping[30] ; Shen, Yan[30] ; Wen, Yang[7,8] ; Chu, Minjie[7,8] ; Yu, Jiang[31] ; Hu, Xiaoxia[32] ; Fan, Yujuan[33] ; He, Hongying[34] ; Jiang, Yanming[35] ; Lei, Zhiying[36] ; Liu, Cui[37] ; Chen, Jianhua[2,38] ; Zhang, Yuan[39] ; Yi, Cunjian[40] ; Chen, Shuangyun[41] ; Li, Wenjin[2] ; Wang, Daowen[12] ; Wang, Zehua[39] ; Di, Wen[42] ; Shen, Keng[43] ; Lin, Dongxin[10,11] ; Shen, Hongbing[7,8] ; Feng, Youji[26] ; Xie, Xing[14] ; Ma, Ding[1] ;
单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Obstet & Gynecol, Wuhan 430074, Hubei, Peoples R China [2]Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China [3]Shanghai Genome Pilot Inst Genom Hlth, Shanghai, Peoples R China [4]Shanghai Genome Pilot Inst Human Hlth, Shanghai, Peoples R China [5]Changning Mental Hlth Ctr, Shanghai, Peoples R China [6]Guangxi Prov Tumor Hosp, Dept Gynecol Oncol, Nanning, Peoples R China [7]Nanjing Med Univ, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China [8]Nanjing Med Univ, Sch Publ Hlth, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Jiangsu, Peoples R China [9]Sun Yat Sen Univ, Ctr Canc, Dept Gynecol Oncol, Guangzhou 510275, Guangdong, Peoples R China [10]Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100730, Peoples R China [11]Peking Union Med Coll, Beijing 100021, Peoples R China [12]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med, Wuhan 430074, Hubei, Peoples R China [13]Hunan Prov Tumor Hosp, Dept Gynecol Oncol, Changsha, Hunan, Peoples R China [14]Zhejiang Univ, Sch Med, Womens Hosp, Hangzhou 310003, Zhejiang, Peoples R China [15]Hubei Univ Arts & Sci, Affiliated Hosp 1, Xiangyang Cent Hosp, Dept Obstet & Gynecol, Xiangyang, Peoples R China [16]China Med Univ, Shengjing Hosp, Dept Obstet & Gynecol, Shenyang, Peoples R China [17]Tianjin Cent Hosp Gynecol & Obstet, Tianjin, Peoples R China [18]Wuhan Med Ctr Women & Children, Wuhan, Peoples R China [19]Sun Yat Sen Univ, Affiliated Hosp 2, Dept Gynecol Oncol, Guangzhou 510275, Guangdong, Peoples R China [20]Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Obstet & Gynecol, Xian 710049, Peoples R China [21]Cent South Univ, Xiangya Hosp 2, Dept Obstet & Gynecol, Changsha, Hunan, Peoples R China [22]Minist Hlth, Key Lab Blood Safety, Blood Ctr Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China [23]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Epidemiol & Biostat, Minist Educ,Key Lab Environm & Hlth,Sch Publ Hlth, Wuhan 430074, Hubei, Peoples R China [24]Huangshi Cent Hosp, Dept Obstet & Gynecol, Huangshi, Peoples R China [25]Xiaogan Cent Hosp, Dept Obstet & Gynecol, Xiaogan, Peoples R China [26]Hosp Fudan Univ, Dept Gynecol Obstet & Gynecol, Shanghai, Peoples R China [27]Peoples Hosp Shenzhen, Dept Gynecol & Obstet, Shenzhen, Peoples R China [28]Nantong Tumor Hosp, Nantong, Peoples R China [29]Guangxi Maternal & Child Hlth Hosp, Dept Obstet & Gynecol, Nanning, Peoples R China [30]Nanjing Med Univ, Nanjing Matern & Child Hlth Hosp, Nanjing, Jiangsu, Peoples R China [31]181 Hosp Peoples Liberat Army, Maternal & Child Ctr, Guilin, Peoples R China [32]Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Obstet & Gynecol, Nanning, Peoples R China [33]Guangxi Univ Med Sci, Affiliated Hosp 1, Dept Obstet & Gynecol, Nanning, Peoples R China [34]Liuzhou Worker Hosp, Dept Obstet & Gynecol, Liuzhou, Peoples R China [35]Peoples Hosp Liuzhou, Dept Obstet & Gynecol, Liuzhou, Peoples R China [36]Youjiang Med Coll Nationalities, Dept Obstet & Gynecol, Affiliated Hosp, Baise, Peoples R China [37]Red Cross Hosp Yulin City, Dept Obstet & Gynecol, Yulin, Peoples R China [38]Shanghai Inst Mental Hlth, Shanghai, Peoples R China [39]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Obstet & Gynecol, Wuhan 430074, Hubei, Peoples R China [40]First Peoples Hosp Jingzhou City, Dept Obstet & Gynecol, Jinzhou, Peoples R China [41]Taihe Hosp Shiyan, Dept Gynecol Oncol, Shiyan, Peoples R China [42]Shanghai Jiao Tong Univ, Dept Obstet & Gynecol, Renji Hosp, Sch Med, Shanghai 200030, Peoples R China [43]Chinese Acad Med Sci, Dept Obstet & Gynecol, Peking Union Med Coll Hosp, Peking Union Med Coll, Beijing 100730, Peoples R China
出处：
DOI： 10.1038/ng.2687
ISSN：

摘要：
To identify new genetic risk factors for cervical cancer, we conducted a genome-wide association study in the Han Chinese population. The initial discovery set included 1,364 individuals with cervical cancer (cases) and 3,028 female controls, and we selected a 'stringently matched samples' subset (829 cases and 990 controls) from the discovery set on the basis of principal component analysis; the follow-up stages included two independent sample sets (1,824 cases and 3,808 controls for follow-up 1 and 2,343 cases and 3,388 controls for follow-up 2). We identified strong evidence of associations between cervical cancer and two new loci: 4q12 (rs13117307, P-combined,P- stringently matched = 9.69 x 10(-9), per-allele odds ratio (OR)(stringently matched) = 1.26) and 17q12 (rs8067378, P-combined,P- stringently matched = 2.00 x 10(-8), per-allele ORstringently matched = 1.18). We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched = 4.52 x 10(-27), per-allele ORstringently matched = 0.75). Our findings provide new insights into the genetic etiology of cervical cancer.

基金：
Key Basic Research and Development Program Foundation of China (973 Program) from the Ministry of Science and Technology of China [2009CB521808, 2013CB911304]; National Natural Science Foundation of China [81230038, 81025011, 81090414, 30973472, 81071663, 81130022, 81121001, 81230052, 81272302, 31000553, 81172464, 81101964]; Key Projects in the National Science and Technology Pillar Program during the Eleventh Five-Year Plan Period [2008BAI57B01]; High-Tech Research and Development Program of China (863 Program) [2012AA020801, 2012AA02A515]; Fund of the Key Laboratory of Cancer Invasion and Metastasis from Hubei Province and Tongji Hospital [HB001, xkdy28]; Hubei Research and Development Program [2008BCC005, 2009BCC001, 2010BCB006]; Program for Changjiang Scholars and Innovative Research Team in University [IRT1025]; Foundation for the Author of National Excellent Doctoral Dissertation of China [201026]; Program for New Century Excellent Talents in University [NCET-09-0550]; Shanghai Rising-Star Program [12QA1401900]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2012]版：
大类 | 1 区 生物
小类 | 1 区 遗传学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 遗传学
JCR分区：
出版当年[2011]版：
Q1 GENETICS & HEREDITY
最新[2023]版：
Q1 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2011版] 出版当年五年平均 出版前一年[2010版] 出版后一年[2012版]

第一作者：
第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Obstet & Gynecol, Wuhan 430074, Hubei, Peoples R China [2]Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China [3]Shanghai Genome Pilot Inst Genom Hlth, Shanghai, Peoples R China [4]Shanghai Genome Pilot Inst Human Hlth, Shanghai, Peoples R China [5]Changning Mental Hlth Ctr, Shanghai, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Shi Yongyong,Li Li,Hu Zhibin,et al.A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12[J].NATURE GENETICS.2013,45(8):918-U262.doi:10.1038/ng.2687.
APA：
Shi, Yongyong,Li, Li,Hu, Zhibin,Li, Shuang,Wang, Shixuan...&Ma, Ding.(2013).A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.NATURE GENETICS,45,(8)
MLA：
Shi, Yongyong,et al."A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12".NATURE GENETICS 45..8(2013):918-U262

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